上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (4): 485-.doi: 10.3969/j.issn.1674-8115.2012.04.024

• 论著（临床研究） • 上一篇    下一篇

激光辅助孵化对冻融胚胎移植临床结局的影响

谷瑞环, 张爱军, 孙贻娟, 陆小溦, 冯 云   

  1. 上海交通大学 医学院附属瑞金医院生殖医学中心, 上海 200025
  • 出版日期:2012-04-28 发布日期:2012-04-27
  • 通讯作者: 冯 云, 电子信箱: artruijin@yahoo.com.cn。
  • 作者简介:谷瑞环（1983—）, 女, 技师, 硕士；电子信箱: huanbiao2006@yahoo.com.cn。
  • 基金资助:

    上海市科委科研计划项目（10JC1410800）

Effects of laser-assisted hatching on clinical outcomes of frozen-thawed embryo transfer

GU Rui-huan, ZHANG Ai-jun, SUN Yi-juan, LU Xiao-wei, FENG Yun   

  1. Reproductive Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2012-04-28 Published:2012-04-27
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 10JC1410800

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摘要：

目的 探讨激光削薄法辅助孵化（AH）对冷冻第3天胚胎移植结局的影响。方法 选取行第3天冷冻胚胎移植患者的1 024周期，其中964个周期行常规的第3天冻存胚胎移植（非AH组），60个周期于第3天冻存胚胎复苏后，用激光将1/4透明带削薄2/3后移植（AH组）；分析两组的种植率、临床妊娠率、多胎率、活产率、流产率及生化妊娠率。结果 两组的种植率、临床妊娠率、多胎率、活产率、流产率及生化妊娠率分别为43.2%和24.2%、58.3%和43.2%、45.7%和26.9%、78.4%和77.7%、21.6%和22.3%、6.7%和4.4%；其中AH组的种植率、临床妊娠率及多胎率与非AH组比较,差异有统计学意义（P＜0.05）；而活产率、流产率及生化妊娠率高于非AH组，但差异无统计学意义（P＞0.05）。结论 采用激光削薄方法进行AH可以提高冷冻复苏第3天胚胎移植后的种植率及临床妊娠率，而对活产率无明显影响。

关键词: 激光, 辅助孵化, 冻存复苏, 移植

Abstract:

Objective To investigate the effects of artificial thinning by laser-assisted hatching (AH) on the clinical outcomes of frozenthawed embryo transfer on day 3. Methods One thousand and twenty-four cycles undergoing frozen-thawed embryo transfer on day 3 were selected. Nine hundred and sixty-four cycles underwent thawed embryo transfer on day 3 (non-AH group), and the other 60 cycles underwent transfer after artificial thinning by AH (AH group). The rates of implantation, clinical pregnancy, multiple pregnancy, live birth, abortion and biochemistry pregnancy were statistically analysed in two groups. Results The rates of implantation, clinical pregnancy, multiple pregnancy, live birth, abortion and biochemistry pregnancy in two groups were 43.2% and 24.2%, 58.3% and 43.2%, 45.7% and 26.9%, 78.4% and 77.7%, 21.6% and 22.3%, and 6.7% and 4.4% respectively. There were significant differences in the rates of implantation, clinical pregnancy and multiple pregnancy between two groups (P＜0.05). The rates of live birth, abortion and biochemistry pregnancy in AH group were higher than those in non-AH group, while there was no significant difference between two groups (P＞0.05). Conclusion Artificial thinning by AH can increase the rates of implantation and clinical pregnancy, while there is no significantly change in the rate of live birth.

Key words: laser, assisted hatching, frozen-thawed, transfer