上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (7): 940-.doi: 10.3969/j.issn.1674-8115.2012.07.025

• 综述 • 上一篇    下一篇

多形性腺瘤基因锌指蛋白PLAGL2的研究进展

薛明明, 宁仁利, 徐慧莉, 董强刚   

  1. 上海交通大学 医学院附属仁济医院 |上海市肿瘤研究所, 上海 200032
  • 出版日期:2012-07-28 发布日期:2012-08-17
  • 通讯作者: 董强刚, 电子信箱: qgdong@shsci.org。
  • 作者简介:薛明明(1985—), 女, 硕士生；电子信箱: ming19851985ming@163.com。
  • 基金资助:

    国家自然科学基金（30872952）；上海市科委基金（09411961700, 0582nm5800）；上海市卫生局基金（2009198）

Research progress of pleiomorphic adenoma gene zinc finger protein PLAGL2

XUE Ming-ming, NING Ren-li, XU Hui-li, DONG Qiang-gang   

  1. Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China
  • Online:2012-07-28 Published:2012-08-17
  • Supported by:

    National Natural Science Foundation of China, 30872952；Shanghai Science and Technology Committee Foundation, 09411961700, 0582nm5800；Shanghai Municipal Health Bureau Foundation, 2009198

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摘要：

多形性腺瘤基因样蛋白2 (PLAGL2)是一类源于多形性腺瘤基因（PLAG）家族的锌指蛋白，家族成员还包括PLAG1和PLAGL1，三者在结构上高度同源，但具有不同的功能，主要与结合的DNA不同有关。近年来，对于PLAG1、PLAGL1和PLAGL2的结构、功能和作用机制等方面的研究取得了较大进展，且发现PLAGL2与细胞代谢及多种系统性疾病的发生和发展有关，而在肿瘤抑制或肿瘤促进方面存在争议。文章就PLAGL2的结构、转录机制、生物学功能及其与系统性疾病和肿瘤的关系等方面的研究进展进行综述。

关键词: 多形性腺瘤基因样蛋白2, 转录机制, 生物学功能, 肿瘤

Abstract:

Pleiomorphic adenoma genelike 2 (PLAGL2), together with pleiomorphic adenoma gene 1 (PLAG1) and pleiomorphic adenoma genelike 1 (PLAGL1), belong to the zinc finger protein gene family. They are highly homologous in structure, and the differences in function are mainly due to different DNAs they bind. In recent years, great progress has been made in the research of structure, function and mechanism of PLAG1, PLAGL1 and PLAGL2. PLAGL2 has been found to be related to cell metabolism and development of many systemic diseases, while there exists controversy on the role of PLAGL2 in tumors. The research progress of structure, transcription mechanism and biologic function of PLAGL2 and its relationship with systemic diseases and tumor are reviewed in this paper.

Key words: pleiomorphic adenoma gene-like 2, transcription mechanism, biological function, tumor