上海交通大学学报(医学版)

›› 2012, Vol. 32 ›› Issue (7): 952-.doi: 10.3969/j.issn.1674-8115.2012.07.028

• 综述 • 上一篇    下一篇

微粒参与子前期发病机制的研究进展

毛亚静, 杨祖菁   

  1. 上海交通大学 医学院附属新华医院妇产科, 上海 200092
  • 出版日期:2012-07-28 发布日期:2012-08-17
  • 通讯作者: 杨祖菁, 电子信箱: yzujing@sohu.com。
  • 作者简介:毛亚静（1987—）, 女, 硕士生；电子信箱: huangdumaomao@sina.com。

Research progress of pathogenesis of microparticles in preeclampsia

MAO Ya-jing, YANG Zu-jing   

  1. Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2012-07-28 Published:2012-08-17

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摘要：

子前期（PE）是妊娠期特有的多系统功能障碍性疾病，是目前引起母婴死亡的主要原因之一。PE的确切发病机制尚未明确，炎症反应、凝血功能变化、血小板激活和内皮细胞损伤等因素均可能对PE的病理过程产生重要影响，研究证实微粒（MP）在上述过程中起着关键的作用。该文就MP的生成和特性、妊娠期体循环中的含量变化、参与PE发病机制的研究进展进行综述，并展望MP在PE诊断和治疗中的应用前景。

关键词: 微粒, 子前期, 妊娠, 发病机制

Abstract:

Preeclampsia (PE) is a pregnancy-specific multi-system dysfunction disease, which is one of the main causes of maternal and infant mortality. The pathogenesis of PE is not clear, inflammation, coagulation function changes, platelet activation and endothelial damage may have significant impact on the pathological process of PE, and studies have confirmed that microparticles (MP) play an important role in the above process. The research progress of generation and characteristics of MP, the changes of contents of MP in systemic circulation during pregnancy, and the pathogenesis of MP in PE is reviewed, and the prospect of MP in the diagnosis and treatment of PE is explored in this paper.

Key words: microparticles, preeclampsia, pregnancy, pathogenesis