上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (8): 1092-.doi: 10.3969/j.issn.1674-8115.2012.08.028

• 综述 • 上一篇    下一篇

静脉注射用免疫球蛋白在肾脏移植中的应用进展

詹嘉铭, 王祥慧   

  1. 上海交通大学 医学院附属瑞金医院肾脏移植中心, 上海 200025
  • 出版日期:2012-08-28 发布日期:2012-08-29
  • 通讯作者: 王祥慧, 电子信箱: wxh4270@sina.com。
  • 作者简介:詹嘉铭（1987—）, 男, 硕士生；电子信箱: zhanjiaming@msn.com。
  • 基金资助:

    卫生部国际交流与合作课题（IHECC07-001）和上海市科委基金（10DZ2212000）

Research progress of intravenous immunoglobulin application in renal transplantation

ZHAN Jia-ming, WANG Xiang-hui   

  1. Kidney Transplantation Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2012-08-28 Published:2012-08-29
  • Supported by:

    Foundation of International Communication and Cooperation of the Ministry of Health of China, IHECC07-001；Shanghai Science and Tecnology Committee Foundation, 10DZ2212000

PDF (PC)

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摘要：

静脉注射用免疫球蛋白（IVIG）在临床肾脏移植领域的应用主要分为两个方面，即免疫炎症调节和免疫替代治疗。前者主要用于脱敏疗法和治疗抗体介导的排斥反应和激素抵抗性排斥反应；后者主要用于防治移植后低丙种球蛋白血症和感染性并发症。IVIG不仅具有抗菌和抗病毒的防治感染功效，而且可有效地调节免疫反应，将在改善临床肾脏移植预后中发挥不可替代的重要作用。

关键词: 静脉注射用免疫球蛋白, 肾脏移植, 免疫调节, 脱敏疗法, 排斥反应, 低丙种球蛋白血症, 感染

Abstract:

The intravenous immunoglobulin (IVIG) application in renal transplantation is divided into two aspects, immunoregulation of inflammation and immune replacement therapy. The former is mainly used for the desensitization therapy, treatment of antibody-mediated rejection and treatment of steroid-resistant rejection, and the latter is mainly used for the prevention and treatment of hypogammaglobulinemia and infectious complications after renal transplantation. IVIG not only can prevent infection through sterile immunity, but can effectively regulate immune function as well. IVIG is bound to play an increasingly important role in the improvement of prognosis of clinical renal transplantation as its unique feature.

Key words: intravenous immunoglobulin, renal transplantation, immunoregulation, desensitization protocol, rejection, hypogammaglobulinemia, infection