上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2013, Vol. 33 ›› Issue (6): 838-.doi: 10.3969/j.issn.1674-8115.2013.06.028

• 论著（临床研究） • 上一篇    下一篇

鼻息肉组织中CD68的表达及与微血管密度的关系

吴继昌, 王士礼, 蔡昌枰   

  1. 上海交通大学 医学院附属瑞金医院耳鼻喉科， 上海 200025
  • 出版日期:2013-06-28 发布日期:2013-06-28
  • 通讯作者: 王士礼, 电子信箱: shiliwang@online.sh.cn。
  • 作者简介:吴继昌（1976—）, 男， 主治医师， 学士; 电子信箱: benoit_wu@163.com。

Expression of CD68 and its relationship with microvessel density in tissues of nasal polyps

WU Ji-chang, WANG Shi-li, CAI Chang-ping   

  1. Department of Otorhinolaryngology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2013-06-28 Published:2013-06-28

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摘要：

目的 观察慢性鼻窦炎鼻息肉（CRSwNP）患者鼻息肉组织中巨噬细胞表面抗原CD68的表达及微血管密度（MVD），并分析两者的相关性。方法 采用免疫组织化学染色SP法检测73例CRSwNP患者（CRSwNP组）鼻息肉组织中CD68的表达和MVD，以无CRSwNP及变应性疾病史的30例鼻中隔偏曲患者作为对照组。对CRSwNP组患者鼻息肉组织中CD68的表达与MVD进行相关性分析。结果 免疫组织化学染色结果显示，CRSwNP组鼻息肉组织中CD68的表达强度和MVD均显著高于对照组鼻中隔黏膜组织（P<0.01）。CRSwNP患者鼻息肉组织中CD68的表达强度与MVD呈显著正相关（r=0.871，P<0.01）。结论 CRSwNP的发生和发展可能与巨噬细胞活化及微血管增生有关。

关键词: 慢性鼻窦炎鼻息肉, 巨噬细胞, 微血管密度

Abstract:

Objective To detect the expression of macrophage surface antigen CD68 and microvessel density (MVD) in tissues of nasal polyps in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), and explore their correlation. Methods The expression of CD68 and MVD in tissues of nasal polyps in 73 patients with CRSwNP (CRSwNP group) were determined by immunohistochemistry SP method, and 30 patients having nasal septal deviation without CRSwNP and history of allergic diseases were served as control group. The correlation of expression of CD68 with MVD in tissues of nasal polyps in CRSwNP group was explored. Results Immunohistochemical staining revealed that the expression of CD68 and MVD in tissues of nasal polyps in CRSwNP group were significantly higher than those in nasal septal mucosa in control group (P<0.01). There was a significantly positive correlation between the expression of CD68 and MVD in tissues of nasal polyps in CRSwNP group (r=0.871, P<0.01). Conclusion The development of CRSwNP may be associated with the activation of macrophages and angiogenesis.

Key words: chronic rhino-sinusitis with nasal polyps, macrophage, microvessel density