上海交通大学学报(医学版)

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血栓调节蛋白对脓毒症治疗作用的研究进展

卢化祥,贾一韬,姚 敏,方 勇   

  1. 上海交通大学 医学院附属第三人民医院灼伤整形科, 上海 201900
  • 出版日期:2013-07-28 发布日期:2013-08-22
  • 通讯作者: 方勇, 电子信箱: fangyong1020@hotmail.com。
  • 作者简介:卢化祥(1989—),男,硕士生; 电子信箱: luhuaxiang2006@126.com。

Application of thrombomodulin in treatment of sepsis

LU Hua-xiang, JIA Yi-tao, YAO Min, FANG Yong   

  1. Department of Burns and Plastic Surgery, the Third People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201900, China
  • Online:2013-07-28 Published:2013-08-22

摘要:

脓毒症是由感染及系统性炎症反应引起的临床综合征。脓毒症患者的凝血系统及炎症反应均发生异常,两者互为影响,在脓毒症的发生和发展中起着重要的作用。血栓调节蛋白作为凝血系统中重要的调节因子,它通过直接与间接的途径发挥抗炎和抗凝的双重作用,为脓毒症的治疗提供了一个新的方向。该文就血栓调节蛋白的结构、功能及其对脓毒症的治疗作用和临床研究进展进行综述。

关键词: 血栓调节蛋白, 脓毒症, 抗炎, 抗凝

Abstract:

Sepsis is a clinical syndrome which results from severe infection and systemic inflammatory response. Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Thrombomodulin is an endogenous anticoagulant protein that possesses both anti-inflammatory and anticoagulant properties in directly and indirectly ways, which provides a new choice for the treatment of sepsis. The structure, function and application of thrombomodulin in the treatment of sepsis are introduced in this paper.

Key words: thrombomodulin, sepsis, anti-inflammation, anti-coagulation