上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

粒细胞肉瘤9例临床分析及文献复习

孙翠娥，唐晓文，孙爱宁，仇惠英，金正明，傅琤琤，马 骁，何广胜，吴德沛   

  1. 苏州大学附属第一医院血液科  江苏省血液研究所  卫生部血栓与止血重点实验室， 苏州 215006
  • 出版日期:2013-09-28 发布日期:2013-09-29
  • 通讯作者: 吴德沛, 电子信箱: wudepei@medmail.com.cn。
  • 作者简介:孙翠娥（1968—），女，副主任医师，学士; 电子信箱: jsdfsdq@126.com；现在江苏省大丰人民医院血液肿瘤科工作。唐晓文（1969—），女，主任医师，博士; 电子信箱: xwtang1020@163.com。
  • 基金资助:

    国家自然科学基金（81270645）；江苏省自然科学基金（BK2012627）；江苏省高校自然科学研究（11KJB320015）；江苏省卫生厅科研项目（H201125）

Clinical analysis and literature review of granulocytic sarcoma with nine cases report

SUN Cui-e, TANG Xiao-wen, SUN Ai-ning, QIU Hui-ying, JIN Zheng-ming, FU Zheng-zheng, MA Xiao, HE Guang-sheng, WU De-pei   

  1. Department of Hematology, the First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou 215006, China
  • Online:2013-09-28 Published:2013-09-29
  • Supported by:

    National Natural Science Foundation of China, 81270645; Natural Science Foundation of Jiangsu Province, BK2012627; Jiangsu Province College Natural Science Research Foundation, 11KJB320015; Jiangsu Provincial Health Department Foundation, H201125

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摘要：

目的 探讨粒细胞肉瘤（GS）的诊断和治疗方法。方法 回顾性分析9例GS患者的临床表现、病理分型、诊断及治疗方法。结果 9例患者均以淋巴结肿大、结外软组织肿块为首发症状。以粒细胞分化和中幼阶段嗜酸粒细胞为GS的特征性病理表现，免疫组织化学检测多为髓过氧化酶、溶菌酶、CD43、CD34、CD56和CD15阳性表达。治疗方法有局部手术切除、放疗以及针对急性髓细胞白血病（AML）的全身性化疗方案。结论 GS的诊断依据为病变组织病理特点，免疫组织化学及骨髓形态学、免疫学分型、细胞遗传学、分子生物学检查，以明确为孤立型或已进展为AML，治疗上以局部手术切除、放疗以及全身性化疗为主。

关键词: 粒细胞肉瘤, 诊断, 治疗

Abstract:

Objective To explore the diagnosis and the treatment options of granulocytic sarcoma (GS). Methods The clinical manifestations, classification of pathological characteristics, diagnosis and treatment of 9 cases with GS were retrospectively analyzed. Results All of the 9 patients presented with lymphadenopathy and soft tissue mass as first symptoms. The pathological feature of GS was the differentiation of granulocytic and medium size mature eosinophils. The majority of GS patients exhibited positive immuno-histological results of myeloperoxidase, lysozyme, CD43, CD34, CD56 and CD15. The therapeutic options included local resection, radiation therapy and systemic chemotherapy with regimen of acute myeloid leukemia (AML). Conclusion The diagnosis of GS depends on the pathologic feature, immunohistochemical characteristics of tissues, morphology, immunology, cytogenetics and molecular biology examinations of bone marrow, in order to define the type of GS (isolated type or AML). The principle treatment options of GS are local resection, radiation therapy and systemic chemotherapy.

Key words: granulocytic sarcoma, diagnosis, therapy