上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

谷胱甘肽系统对冠状动脉病变程度的影响

杨 晖1，赵雅洁2，余 强1，李菲卡2，梁 伟2   

  1. 1.上海瑞金医院集团闵行区中心医院心内科， 上海 201100； 2.上海交通大学  医学院附属瑞金医院老年病科， 上海 200025
  • 出版日期:2013-09-28 发布日期:2013-09-29
  • 通讯作者: 梁 伟, 电子信箱: lw@717.com。
  • 作者简介:杨 晖（1970—），女，主任护师，硕士; 电子信箱: yanghui158@gmail.com。

Impact of glutathione system on coronary heart diseases

YANG Hui1, ZHAO Ya-jie2, YU Qiang1, LI Fei-ka2, LIANG Wei2   

  1. 1.Department of Cardiology, Central Hospital of Minhang District, Ruijin Hospital Group, Shanghai 201100, China; 2.Department of Gerontology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2013-09-28 Published:2013-09-29

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摘要：

目的 探讨谷胱甘肽系统对冠状动脉病变程度的影响。方法 选取179例行冠状动脉造影术的患者，根据年龄分为老年组（≥60岁，n=102例）和非老年组（<60岁，n=77），检测患者的血液生化指标以及还原型谷胱甘肽（GSH）、谷胱甘肽还原酶（GR）和谷胱甘肽过氧化物酶（GSH-Px）的活性。根据冠状动脉造影结果，采用Gensini评分系统对每支血管病变程度进行定量评分。结果 两组患者的血生化指标比较差异均无统计学意义（P>0.05）。老年组患者的血浆GSH、GR和GSH-Px活性均显著低于非老年组，差异有统计学意义（P<0.05）；校正年龄因素后，血浆GSH、GSH-Px和GR活性与Gensini积分之间仍呈显著负相关性（r=－0.721、－0.743和－0.724，P<0.001）。根据Gensini积分进行四分位分组，发现随着Gensini积分值的增高，GSH、GSH-Px及GR活性均呈逐渐下降趋势（P<0.001）。多元线性回归分析显示GSH-Px活性对Gensini积分的影响作用最大。结论 随着年龄增长，血浆GSH、GR和GSH-Px活性明显降低，与冠状动脉病变程度具有一定的负相关性，且GSH-Px活性对冠状动脉病变的影响作用更大。

关键词: 谷胱甘肽过氧化物酶, 还原型谷胱甘肽, 谷胱甘肽还原酶, 衰老, 冠状动脉病变, Gensini积分

Abstract:

Objective To investigate the impact of glutathione system on coronary heart disease. Methods One hundred and seventy-nine patients undergoing coronary angiography were selected, and were divided into elder group (≥60 years old, n=102) and non-elder group (<60 years old, n=77). The blood biochemical parameters were examined, and the activity of  glutathione peroxidase (GSH-Px), glutathione (GSH) and glutathione reductase (GR) was detected. The severity of coronary atherosclerosis was determined by Gensini score system based on the findings of coronary angiography. Results There was no significant difference in blood biochemical parameters between two groups (P>0.05). The plasma activity of  GSH, GSH-Px and GR in elder group was significantly lower than that in non-elder group (P<0.05). After adjustment for age, the plasma activity of GSH, GSH-Px and GR  was significantly negatively related to Gensini scores (r=－0.721, －0.743 and －0.724; P<0.001). Based on the quartile of Gensini scores, with the increase of Gensini scores, the activity of GSH, GSH-Px and GR decreased gradually (P<0.001). Multiple linear regression analysis indicated that the activity of GSH-Px had the greatest impact on Gensini scores. Conclusion With the age increase, the plasma activity of GSH, GSH-Px and GR significantly decreases, and is negatively related to the severity of coronary artery stenosis, especially for GSH-Px.

Key words: glutathione peroxidase, glutathione, glutathione reductase, aging, coronary heart disease, Gensini score