上海交通大学学报（医学版）

上海交通大学学报（医学版）

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壬基苯酚雌性生殖毒性的研究进展

程淑群，张志浩，夏茵茵   

  1. 重庆医科大学 公共卫生与管理学院， 重庆 400016
  • 出版日期:2014-04-28 发布日期:2014-05-13
  • 通讯作者: 夏茵茵, 电子信箱: kendraxia@163.com。
  • 作者简介:程淑群 (1971—)， 女， 副教授， 博士; 电子信箱: 871222238@qq.com。

Advances of nonylphenol toxicity on the female reproductive system

CHENG Shu-qun, ZHANG Zhi-hao, XIA Yin-yin   

  1. School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
  • Online:2014-04-28 Published:2014-05-13

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摘要：

壬基苯酚（NP）是一种环境内分泌干扰物，主要来自于壬基酚聚氧乙烯醚(NPEOs)的生物降解。NPEOs为非离子表面活性剂，被广泛用于化学工业方面，制备合成洗涤剂、润滑油添加剂和增塑剂等。壬基苯酚具有雌激素样作用，可能对雌性生殖系统产生影响及危害；虽然具体作用机制尚未阐明，但壬基苯酚对人体的潜在危害不容忽视。文章就壬基苯酚在雌性生殖毒性方面的研究进展进行综述，为减少壬基苯酚的排放和逐步找寻替代品提供依据。

关键词: 壬基苯酚, 环境内分泌干扰物, 雌性生殖系统

Abstract:

Nonylphenol (NP) is an environmental endocrine disrupting chemical (ED), which mainly comes from the biodegradation of nonylphenol ethoxylates (NPEOs). As nonionic surfactants, NPEOs are widely used in chemical products, such as detergent, lubricant additives, and plastics additives. NP has estrogenic activity, so it may influence and harm the female reproductive system. Although the mechanism of its estrogenic activity is not very clear，the adverse effects of NP on human bodies should not be ignored. This paper reviews the researches on the reproductive toxicity of NP, and provides evidence for reducing the NP emission and finding alternatives.

Key words: nonylphenol, environmental endocrine disruptors, female reproductive system