上海交通大学学报（医学版）

上海交通大学学报（医学版）

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5-HT1A受体对抑郁焦虑行为的调节作用及其机制

苏晖1,2,施慎逊2   

  1. 1 上海交通大学 医学院附属精神卫生中心， 上海 200030； 2 复旦大学附属华山医院精神医学科， 上海 200040
  • 出版日期:2015-09-28 发布日期:2015-09-30
  • 通讯作者: 施慎逊, 电子信箱: shishenxun@163.com。
  • 作者简介:苏晖（1972—）， 女， 副主任医师， 博士生; 电子信箱: suhui_cn@hotmail.com。

Regulatory effect of serotonin 1A receptor on depression and anxiety behaviors and relevant mechanisms

SU Hui1，2, SHI Shen-xun2   

  1. 1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2.Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Online:2015-09-28 Published:2015-09-30

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摘要：

5-羟色胺（5-HT）水平异常引起的神经递质-受体信号通路的适应性改变涉及大脑功能紊乱和神经精神疾病产生，与抑郁症、焦虑症的发病机制密切相关。5-HT1A受体是脑内分布最广的5-HT受体亚型，已是临床抑郁焦虑障碍药物治疗的重要靶点。本文从电生理学、转基因动物学、信号通路、药理学角度综述5-HT1A受体对抑郁焦虑的调节作用及其机制，有助于深入理解5-HT1A受体功效。

关键词: 5-HT1A受体, 抑郁, 焦虑, 调节

Abstract:

Abnormal level of serotonin (5-HT) causes adaptive changes of neurotransmitter-receptor signaling pathways, which involve brain dysfunction and neuropsychiatric disorders and closely relate to the pathogenesis of anxiety and depression disorders. Serotonin 1A (5-HT1A) receptor is the most widely distributed subtype of serotonin receptor in the brain and has become an important target for drug treatment of anxiety and depression disorders. This paper reviews the regulatory effect of 5-HT1A receptor on depression and anxiety and relevant mechanisms from perspectives of electrophysiology, transgenic zoology, signaling pathways, and pharmacology, which are helpful for thoroughly understanding functions of 5-HT1A receptor.

Key words: serotonin 1A , receptor, depression, anxiety, modulation