上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2015, Vol. 35 ›› Issue (10): 1491-.doi: 10.3969/j.issn.1674-8115.2015.10.012

• 论著（临床研究） • 上一篇    下一篇

INSIG2基因与氯氮平相关代谢综合征的关联研究

杨琳1,2，陈剑华1，王振1，杨卫敏1，施慎逊2，徐一峰1,2   

  1. 1.上海交通大学 医学院附属精神卫生中心， 上海市重性精神病重点实验室， 上海200030； 2.复旦大学附属华山医院精神医学教研室， 上海200040
  • 出版日期:2015-10-20 发布日期:2015-12-22
  • 作者简介: 杨琳(1979—)， 女， 主治医师， 博士生; 电子信箱: yanglin828@aliyun.com
  • 基金资助:

     国家自然科学基金面上项目(81171271)；上海市重性精神病重点实验室（13dz260500）；上海市卫计委科研项目（201440552）

Study on the correlation between INSIG2 and metabolic syndrome

YANG Lin1,2, CHEN Jian-hua1, WANG Zhen1, YANG Wei-min1, SHI Shen-xun2, XU Yi-feng1,2   

  1. 1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, China; 2.Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai200021, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    National Natural Science Foundation of China, 81171271； Shanghai Key Laboratory of Psychotic Disorders, 13dz2260500； the Research Project of Shanghai Municipal Health and Family Planning Commission， 201440552

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摘要：

目的在中国汉族精神分裂症患者人群中，探讨INSIG2基因多态性与服用氯氮平相关代谢综合征的关系。方法入组621例服用氯氮平1年以上的精神分裂症患者，收集病史及临床资料，进行代谢指标测定。选择INSIG2基因的8个单核苷酸多态性（SNP）位点进行分型检测。所有数据以代谢综合征诊断标准进行分组，采用SPSS 17.0统计软件包及SHEsis软件进行统计分析。结果621例服用氯氮平的精神分裂症患者出现代谢综合征的比例为41.8%。INSIG2基因rs17587100位点在校正相关临床资料后，其等位基因及基因型在组间的分布频率存在差异(P<0.05)，但进行多重假设检验FDR校正后差异未见统计学意义(P>0.05)。结论本研究未发现INSIG2基因多态性与氯氮平相关的代谢综合征存在关联。

关键词: 精神分裂症, 代谢综合征, 氯氮平, INSIG2

Abstract:

ObjectiveTo investigate the correlation between the polymorphism of insulin induced gene 2 (INSIG2) and metabolic syndrome (MetS) relevant to administration of clozapine for Han Chinese patients with schizophrenia.MethodsMedical histories and clinical data of 621 schizophrenia patients treated with clozapine for at least one year were enrolled and metabolic indexes were measured. Eight single nucleotide polymorphisms (SNPs) of INSIG2 were genotyped. All data was grouped according to the criteria of metabolic syndrome and statistically analyzed by SPSS 17.0 and SHEsis. ResultsThe incidence of MetS of 621 schizophrenia patients treated with clozapine was 41.8%. The allelic and genotypic frequencies of locus rs17587100 of INSIG2 between two groups were different after relevant clinical data was adjusted (P<0.05). However, the differences were not statistically significant after False Discovery Rate (FDR) correction of multiple hypothesis testing (P>0.05). ConclusionThe polymorphism of INSIG2 doesn’t correlate with MetS relevant to administration of clozapine.

Key words: schizophrenia, metabolic syndrome, clozapine, INSIG2