上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2015, Vol. 35 ›› Issue (10): 1556-.doi: 10.3969/j.issn.1674-8115.2015.10.025

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Ras信号通路与抑郁症神经可塑性机制

王凡，张晨，方贻儒   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科， 上海200030
  • 出版日期:2015-10-20 发布日期:2015-12-22
  • 通讯作者: 方贻儒, 电子信箱: yirufang@gmail.com
  • 作者简介:王凡（1990—）， 女， 硕士生; 电子信箱: beauty-2008@hotmail.com
  • 基金资助:

    国家自然科学基金（91232719）；国家临床重点专科-上海市精神卫生中心（卫生部医政司2011-873）；科技部“十二五”国家科技支撑项目 (2012BAI01B04)

Ras signaling pathway and neural plasticity mechanism of depression

WANG Fan, ZHANG Chen, FANG Yi-ru   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine， Shanghai 200030， China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    National Natural Science Foundation of China, 91232719; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873; National Key Technology Research and Development Program of the Ministry of Science and Technology of China in the “12th Five-Year Plan”, 2012BAI01B04

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摘要：

抑郁症的确切病因及病理机制尚不清楚。近几年，越来越多的证据提示神经可塑性机制在抑郁症发病及治疗中的作用，其中神经营养因子在神经可塑性中发挥着极其重要的作用。Ras相关信号通路作为一条重要的神经营养因子受体下游信号通路在神经可塑性中发挥着重要的作用。该文对Ras信号通路与抑郁症神经可塑性机制的相关研究进行综述。

关键词: 抑郁症, Ras信号通路, 神经可塑性, 神经营养因子

Abstract:

The pathogenesis of depression has not been clearly elucidated yet. In recent years, more and more evidences highlight the role of neural plasticity mechanism in the pathogenesis and treatment of depression. Particularly, neurotrophic factors are critical for the neural plasticity. Meanwhile the Ras signaling pathway, a vital downstream signaling pathway of the neurotrophic factor receptor, plays an important role in the neural plasticity. This paper reviews studies relevant to Ras signaling pathways and the neural plasticity mechanism of depression.

Key words: depression, Ras signaling pathways, neural plasticity, neurotrophic factors