上海交通大学学报（医学版）

上海交通大学学报（医学版）

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肿瘤标志物在结直肠癌诊断中的作用

蒋奕玫，赵任   

  1. 上海交通大学 医学院附属瑞金医院北院普外科， 上海 201801
  • 出版日期:2015-11-28 发布日期:2016-01-13
  • 通讯作者: 赵任, 电子信箱: zhaorensurgeon@aliyun.com。
  • 作者简介:蒋奕玫（1986—）， 女， 住院医师， 硕士生; 电子信箱: 06crissi@sina.com。
  • 基金资助:

    上海申康医院发展中心郊区三级医院临床能力建设项目（SHDC12013907）

Predictive values of tumor markers in colorectal cancer

JIANG Yi-mei, ZHAO Ren   

  1. Department of Surgery， Ruijin Hospital North， Shanghai Jiao Tong University School of Medicine， Shanghai 201801， China
  • Online:2015-11-28 Published:2016-01-13
  • Supported by:

    Clinical Construction Project for Tertiary Hospitals in Suburbs of Shanghai Hospital Development Center, SHDC12013907

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摘要：

结直肠癌（CRC）是最常见的消化系统恶性肿瘤。目前认为，CRC如能早期诊断，仍有可能治愈。肿瘤标志物是一类可以反映肿瘤生物学行为的分子，可以某种程度地反映肿瘤的有无。肿瘤标志物检测创伤小，但敏感度和特异度有待提高。近年来，无论在蛋白水平，还是基因水平，均发现了许多CRC的肿瘤标志物，该文对此进行综述。

关键词: 结直肠癌；肿瘤标志物, 诊断；筛查

Abstract:

Colorectal cancer (CRC) is the most common malignant tumor of digestive system. At present, it is generally accepted that CRC is still curable if it can be early diagnosed. Tumor markers are molecules that reflect the biological behaviors of tumors and can predict tumors to a certain extent. Test of tumor markers is less invasive, but the sensitivity and specificity need to be improved. In recent years, many tumor markers of CRC have been detected not only at the protein level, but also at the gene level. This article reviews research progresses.

Key words: colorectal cancer, tumor marker, diagnosis, screening