上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

社区精神分裂症患者代谢性疾病及生存质量现况调查

朱云程，曹爱爱，王芳，薛连学，陈玄玄，江茜茜，季卫东   

  1. 上海市长宁区精神卫生中心, 上海交通大学BIO-X中心附属绿地医院， 上海 200335
  • 出版日期:2016-06-28 发布日期:2016-07-25
  • 通讯作者: 江茜茜, 电子信箱: xixi19850101.student@sina.com。
  • 作者简介:朱云程（1984—）， 男， 主治医师， 硕士; 电子信箱: hellfiregenius@163.com。
  • 基金资助:

    上海市长宁区卫生和计划生育委员会科研课题（20134Q06001）

Investigation of metabolic diseases and quality of life in patients with schizophrenia

ZHU Yun-cheng， CAO Ai-ai， WANG Fang， XUE Lian-xue， CHEN Xuan-xuan， JIANG Xi-xi， JI Wei-dong   

  1. Shanghai Changning District Mental Health Center， Green Land Hospital of BIO-X Center, Shanghai Jiao Tong University， Shanghai 200335， China
  • Online:2016-06-28 Published:2016-07-25
  • Supported by:

    Project of Shanghai Changning District Health and Family Planning Commission， 20134Q06001

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摘要：

目的 通过对社区精神分裂症患者代谢指标和生存质量的评定，调查患者代谢特征和生存质量现况及其相关性。方法 根据非代谢综合征（Non-MS）、高危代谢综合征（HR-MS）或代谢综合征（MS）的诊断，对174例患者进行分组。分析代谢指标（体质量指数、平均动脉压、胆固醇、三酰甘油和空腹血糖）与世界卫生组织生存质量测定量表简表评分（WHOQOL-BREF）的关系。结果 WHOQOL-BREF评分的组间差异有统计学意义（F=5.903，P=0.000）；Post-Hoc检验显示Non-MS组的WHOQOL-BREF评分显著低于HR-MS组和MS组（P=0.009，P=0.002），HR-MS组与MS组WHOQOL-BREF评分的差异无统计学意义（P=0.153）。平均动脉压、空腹血糖值与WHOQOL-BREF评分呈负线性相关(r=-0.183，P=0.015；r=-0.168， P=0.026)。结论 精神分裂症患者任意一项代谢性指标异常均可伴发相关代谢性指标的协同改变，并伴有生存质量的下降。糖尿病、高血压对患者生存质量的影响相对于肥胖、高脂血症更加显著。

关键词: 精神分裂症, 代谢综合征, 生存质量, 社区

Abstract:

Objective To investigate the current situation and correlation of metabolic characteristics and quality of life (QOL) in patients with schizophrenia by assessing metabolic indexes and QOL. Methods One hundred and seventy-four patients were assigned according to the diagnoses of non-metabolic syndrome (Non-MS group), high-risk-metabolic syndrome (HR-MS group), and metabolic syndrome (MS group). The correlations between metabolic indexes (body mass index, mean arterial pressure, cholesterol, triglyceride, and fasting blood glucose) and the WHO Quality of Life-BREF (WHOQOL-BREF) score were analyzed. Results The differences in the WHOQOL-BREF score among groups were statistically significant (F=5.903，P=0.000). Post-Hoc test showed that the WHOQOL-BREF score was lower in the Non-MS group than in the HR-MS group and the MS group (P=0.009, P=0.002). The difference in the WHOQOL-BREF score between the HR-MS group and the MS group was not statistically significant (P=0.153). The mean arterial pressure and fasting blood glucose were negatively and linearly correlated to the WHOQOL-BREF score (r=-0.183，P=0.015；r=-0.168， P=0.026).  Conclusion The abnormality of any one of metabolic indexes can cause synergistic changes in associated metabolic indexes with decreased QOL in patients with schizophrenia. The effects of diabetes and hypertension on QOL of patients are more significant as compared with obesity and hyperlipemia.

Key words: schizophrenia, metabolic syndrome, quality of life, community