上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

多囊卵巢综合征患者血清鸢尾素水平的相关研究

宋梦鸽，丘彦   

  1. 重庆医科大学附属第一医院生殖健康与不孕症专科， 重庆 400016
  • 出版日期:2016-06-28 发布日期:2016-07-25
  • 通讯作者: 丘彦, 电子信箱: cqartq@ 163.com。
  • 作者简介:宋梦鸽(1988—)，女，硕士生; 电子信箱: songmenggezi@163.com。

Study on the serum irisin level in patients with polycystic ovary syndrome

SONG Meng-ge, QIU Yan   

  1. Department of Assistant Reproductive Centre， the First Affiliated Hospital， Chongqing Medical University， Chongqing 400016， China
  • Online:2016-06-28 Published:2016-07-25

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摘要：

目的 探讨多囊卵巢综合征(PCOS)患者血清鸢尾素水平及其与代谢参数的关系，观察二甲双胍治疗前后PCOS患者血清鸢尾素水平的变化情况。方法 选择79例PCOS患者（PCOS组）和57例月经周期规则的输卵管性不孕患者（对照组）作为研究对象。PCOS组中26例肥胖或伴胰岛素抵抗患者接受二甲双胍(500 mg, 3次/d)治疗, 疗程6个月。比较2组患者血清鸢尾素水平及相关指标，观察二甲双胍治疗前后PCOS患者血清鸢尾素水平及相关指标的变化。结果 PCOS组血清鸢尾素水平明显高于对照组（P=0.000），且PCOS组肥胖患者血清鸢尾素水平高于非肥胖患者（P=0.001）。二甲双胍治疗6月后，PCOS患者血清鸢尾素水平显著下降，胰岛素抵抗情况有所改善。相关性分析结果显示血清鸢尾素水平与稳态模型评估的胰岛素抵抗指数(HOMA-IR)呈正相关（r=0.240, P=0.033）。结论 PCOS患者血清鸢尾素水平明显升高且与HOMA-IR呈正相关，可能与胰岛素抵抗的发生和发展有关；二甲双胍治疗可显著降低PCOS患者血清鸢尾素水平。

关键词: 多囊卵巢综合征, 鸢尾素, 二甲双胍

Abstract:

Objective  To investigate the correlation between the serum irisin level and the metabolic parameters in patients with polycystic ovarian syndrome (PCOS) and observe changes in the serum irisin level before and after metformin treatment.  Methods A total of 79 patients with PCOS (the PCOS group) and 57 patients with tubal infertility and regular menstruation (the control group) were enrolled. Twenty-six PCOS patients with obesity or insulin resistance (IR) received 6 months treatment of oral metformin (500 mg tid). The serum irisin level and relevant indexes were compared between the two groups and their changes before and after treatment with metformin were observed.  Results The serum irisin level in the PCOS group was significantly higher than that in the control group (P=0.000) and the serum irisin level in PCOS patients with obesity was higher than that in PCOS patients without obesity (P=0.001). After 6 months of metformin treatment, PCOS patients had a significant decrease in serum irisin level and improved IR. Correlation analysis revealed that the serum irisin level had a positive correlation with HOMA-IR (r=0.240, P=0.033). Conclusion The serum irisin level in PCOS patients significantly increases and has a positive correlation with HOMA-IR, which may be associated with the occurrence and development of IR. The metformin treatment can significantly decrease the serum irisin level in PCOS patients.

Key words: polycystic ovary syndrome, irisin, metformin