上海交通大学学报（医学版）

上海交通大学学报（医学版）

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脂氧素在急性肺损伤中作用及机制的研究进展

张蓉，章怡苇，汪燕，祁爱花，王莉，王爱忠   

  1. 上海交通大学附属第六人民医院麻醉科， 上海 200233
  • 出版日期:2016-06-28 发布日期:2016-07-25
  • 通讯作者: 王爱忠, 电子信箱: w19680420@sohu.com。
  • 作者简介:张蓉（1991—）， 女， 硕士生; 电子信箱: lotuszhangrong@163.com。
  • 基金资助:

    国家自然科学基金（81272147）

Research advances in the roles of lipoxin in acute lung injury and its mechanisms

ZHANG Rong, ZHANG Yi-wei, WANG Yan, QI Ai-hua, WANG Li, WANG Ai-zhong   

  1. Department of Anesthesiology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2016-06-28 Published:2016-07-25
  • Supported by:

    National Natural Science Foundation of China, 81272147

PDF (PC)

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摘要：

急性肺损伤(ALI)及其严重阶段的急性呼吸窘迫综合征(ARDS)是以非心源性肺水肿和顽固性低氧血症为主要特征的一种常见的危重症疾病，死亡率高，严重威胁患者生命。脂氧素(LX)作为一种有效的内源性反调节脂质介质，在多种疾病如ALI/ARDS的病理过程中发挥重要作用，是近年来研究的热点。该文就LX在ALI/ARDS中作用及机制的研究进展进行简要综述。

关键词: 脂氧素, 急性肺损伤, 急性呼吸窘迫综合征, 炎症反应, 促炎症消退

Abstract:

Acute lung injury (ALI) and its severe phase, i.e. acute respiratory distress syndrome (ARDS), is a common critical disease characterized by noncardiac pulmonary edema and refractory hypoxemia with high mortality, which seriously threatens patients’ lives. As a potent endogenous counter-regulatory lipid mediator, lipoxin (LX) plays a key role in the pathogenesis of many diseases such as ALI/ARDS and becomes a research focus in recent years. This paper reviews research advances in the roles of LX in ALI/ARDS and its mechanisms.

Key words: lipoxin, acute lung injury, acute respiratory distress syndrome, inflammation, pro-resolution