上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

妊娠期糖尿病的危险因素分析

#br# 罗明娟1,2，胡园园2，吴雪琴3，顾建芬1，梁 伟1，陈健浩4，罗 琼4，黄晓青2，胡 承5   

  1. 1. 香港大学 深圳医院内分泌与代谢科，深圳 518053；2. 深圳龙岗中心医院内分泌与代谢科，深圳 518116；3. 深圳龙岗中心医院妇产科，深圳 518116；4. 香港大学 深圳医院妇产科，深圳 518053；5. 上海交通大学 附属第六人民医院，上海市糖尿病研究所，上海 200233
  • 出版日期:2016-08-29 发布日期:2016-08-31
  • 通讯作者: 黄晓青，电子信箱：xiaoqing_szhuang@163.com；胡承，电子信箱：alfredhc@sjtu.edu.cn。
  • 作者简介:罗明娟（1983—），女，主治医师，硕士生；电子信箱：luomj@hku-szh.org。
  • 基金资助:

    国家自然科学基金（81322010）；深圳市医疗卫生类科研项目（201303210）；上海市教育委员会高峰高原学科建设计划（20152527）

Analysis of the possible risk factors of gestational diabetes mellitus

LUO Ming-juan1,2, HU Yuan-yuan2, WU Xue-qin3, GU Jian-fen1, LIANG Wei1, CHIN Robert4, LUO Qiong4, HUANG Xiao-qing2, HU Cheng5   

  1. 1. Department of Endocrinology and Metabolism, Shenzhen Hospital, University of Hong Kong, Shenzhen 518053, China; 2. Department of Endocrinology and Metabolism, Longgang District Central Hospital, Shenzhen 518116, China; 3. Department of Obstetrics and Gynecology, Longgang District Central Hospital, Shenzhen 518116, China; 4. Department of Obstetrics and Gynecology, Shenzhen Hospital, University of Hong Kong, Shenzhen 518053, China; 5. Shanghai Diabetes Institute, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

  • Online:2016-08-29 Published:2016-08-31
  • Supported by:

    National Natural Science Foundation of China, 81322010; Shenzhen Medical Research Program, 201303210; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152527

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摘要：

目的·探讨深圳地区妊娠期糖尿病（GDM）的危险因素。方法·选择2014年2月—2015年7月深圳地区住院待产的432例GDM患者及409例正常血糖（NGT）孕妇，收集孕妇资料，检测孕妇孕早期空腹血糖及糖化血红蛋白、孕24～28周口服葡萄糖耐量试验（OGTT），采用Logistic回归分析法探讨GDM的危险因素。结果·GDM组的年龄、孕前体质量、孕前BMI高于NGT组（均P=0.000），2组分娩前体质量和分娩前BMI差异无统计学意义。Logistic单因素分析显示，2组在既往GDM史、孕前超重（BMI≥25 kg/m2）、糖尿病家族史、高龄（年龄≥35岁）方面比较，差异具有统计学意义；进一步采用Logistic多因素分析显示，既往GDM史、孕前超重、糖尿病家族史、高龄是GDM的危险因素（均P<0.05）。结论·既往GDM史、孕前超重、糖尿病家族史、高龄是GDM的危险因素。

关键词: 糖尿病, 妊娠, 危险因素

Abstract:

Objective · To explore the risk factors for gestational diabetes mellitus (GDM) in Shenzhen. Methods · Four hundred and thirty-two GDM pregnant women and 409 pregnant women with normal glucose tolerance (NGT) who delivered from February 2014 to July 2015 in two hospitals in Shenzhen were enrolled. The data of pregnant women were collected. FBG and HbA1c in the first trimester and OGTT during 24-28 weeks’ gestation were tested. Logistic regression analysis was used to analyze the risk factors for GDM. Results · The age, pre-pregnant body weight and pre-pregnant BMI were higher in the GDM group than in the NGT group (P=0.000 for all). The differences in body weight and BMI before delivery between two groups were not statistically significant. The univariate Logistic regression analysis showed that there were statistical differences in GDM history, pre-pregnant overweight (BMI≥25 kg/m2), diabetes family history, and age≥35 years between two groups. The multivariate Logistic regression analysis indicated that GDM history, pre-pregnant overweight, diabetes family history, and age≥35 years were risk factors for GDM (P<0.05 for all). Conclusion · GDM history, pre-pregnant overweight, diabetes family history, and age≥35 years are the risk factors for GDM.

Key words: diabetes, gestational, risk factors