上海交通大学学报(医学版)

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肝干细胞和精原干细胞在肝脏疾病治疗中的应用

张桢珍, 陈政, 袁青青, 孙敏, 牛明辉, 何祖平   

  1. 上海交通大学  医学院附属仁济医院癌基因与相关基因国家重点实验室,Med-X-仁济医院临床干细胞研究中心, 上海 200127
  • 出版日期:2016-09-28 发布日期:2016-10-31
  • 通讯作者: 何祖平, 电子信箱: zupinghe@sjtu.edu.cn。
  • 作者简介:张桢珍(1985—), 女, 博士后; 电子信箱: zhenzhen4913@yahoo.com。
  • 基金资助:

     国家自然科学基金(31171422);上海市教育委员会高峰高原学科建设计划(20152511)

Application of hepatic stem cells and spermatogonial stem cells in treatment of liver disease

ZHANG Zhen-zhen, CHEN Zheng, YUAN Qing-qing, SUN Min, NIU Ming-hui, HE Zu-ping   

  1. State Key Laboratory of Oncogenes and Related Genes, Med-X-Renji Hospital Clinical Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2016-09-28 Published:2016-10-31
  • Supported by:

    National Nature Science Foundation of China,31171422; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support,20152511

摘要:

供体肝脏和肝细胞的严重短缺是限制其治疗肝脏疾病的最大难题。肝外组织来源的干细胞可作为肝细胞的重要来源,为肝病的治疗带来新的希望。该文根据国内外研究动态,并结合自己的研究综述了肝干细胞、精原干细胞及其他干细胞在肝脏疾病治疗中的研究进展,并展望了其未来的研究方向。

关键词: 肝干细胞, 精原干细胞, 肝病, 细胞治疗

Abstract:

Severe shortage of liver donors and hepatocytes has become a major handicap for the treatment of liver disease. Extra-liver tissues and stem cells can provide an essential source of hepatocytes, which brings new promise for treating liver-related disease. Here we address the advances on the potential application of hepatic stem cells, spermatogonial stem cells, and other stem cells in the treatment of liver disease and future research directions based on studies from home and abroad, as well as our research.

Key words: hepatic stem cells, spermatogonial stem cells, liver disease, cell therapy