上海交通大学学报(医学版)

• 论著(临床研究) • 上一篇    下一篇

CD147在三阴性乳腺癌中的表达及其与预后的关系

汪成 1, 2,单鸣 2,牛瑞洁 2,叶曼娜 3,徐明 3,庄志刚 4   

  1. 1.同济大学医学院,上海 200092;2.上海市黄浦区中心医院乳腺外科,上海 200002;3.上海市黄浦区中心医院病理科,上海 200002;4.同济大学附属第一妇幼保健院乳腺外科,上海 200050
  • 出版日期:2017-01-28 发布日期:2017-01-19
  • 通讯作者: 庄志刚,电子信箱:zhuang_zg@163.com。
  • 作者简介:汪成(1975—),男,副主任医师,博士生;电子信箱:wangcheng1212@hotmail.com。
  • 基金资助:

    上海市卫生与计划生育委员会科研课题(201540259)

Expression of CD147 in triple-negative breast cancer and its association with the prognosis

WANG Cheng1, 2, SHAN Ming2, NIU Rui-jie2, YE Man-na3, XU Ming3, ZHUANG Zhi-gang4   

  1. 1. Tongji University School of Medicine, Shanghai 200092, China; 2. Department of Breast Surgery, Central Hospital of Huangpu District, Shanghai 200002, China; 3. Department of Pathology, Central Hospital of Huangpu District, Shanghai 200002, China; 4. Department of Breast Surgery, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 200050, China
  • Online:2017-01-28 Published:2017-01-19
  • Supported by:

    Project of Shanghai Municipal Health and Family Planning Commission, 201540259

摘要:

目的 ·探讨CD147在三阴性乳腺癌(TNBC)组织中的表达及其临床意义,分析其与预后的关系。方法 ·收集110例TNBC患者的临床病理及随访资料,进行CD147免疫组织化学检测,分析CD147表达与临床病理特征及预后的关系。结果 · CD147在TNBC组织中的阳性表达率为81.82%(90/110),CD147表达与组织学分级、Ki-67高表达、p53阳性表达呈正相关(P=0.000,P=0.047,P=0.046)。与年龄、肿瘤直径、腋窝淋巴结转移状态无明显相关性(P>0.05)。生存分析结果显示,CD147在TNBC组织中的不同表达强度与总生存率和无病生存率具有一定关系(P=0.024,P=0.001);多元回归分析结果显示,CD147与Ki-67是TNBC预后的风险因子,其阳性表达率越高,患者生存期越短。结论 · CD147在TNBC组织中呈高表达,与预后密切相关,可以作为独立的预后判断因子。CD147抗体的临床应用有可能成为TNBC重要的靶向治疗方法。

关键词:  , CD147;三阴性乳腺癌;免疫组织化学;预后

Abstract:

Objective · To investigate the expression of CD147 and its clinical significance in triple-negative breast cancer (TNBC) tissues and analyze the association between CD147 expression and the prognosis. Methods · Clinicopathological and follow-up data of 110 patients with TNBC were collected. The immunohistochemical assay was performed for CD147 and the association of CD147 expression with clinicopathological characteristics and the prognosis was analyzed. Results · The positive expression rate of CD147 in TNBC tissues was 81.82% (90/110). CD147 expression was positively correlated to histological grade, high expression of Ki-67, and positive expression of p53 (P=0.000, 0.047, and 0.046, respectively) and was not significantly correlated to age, tumor size, and axillary lymph node metastasis (P>0.05). Survival analysis showed that CD147 expression intensity was associated with overall survival and disease-free survival (P=0.024 and 0.001, respectively). Multivariate regression analysis indicated that CD147 and Ki67 were risk factors for the prognosis of TNBC. The higher the positive expression rates were, the shorter the survival was. Conclusion · CD147 is highly expressed in TNBC tissues and is closely associated with the prognosis. It can be used as an independent factor for predicting the prognosis of TNBC. Clinical application of CD147 antibody may be an important target therapy for TNBC in the future.

Key words:  CD147, triple-negative breast cancer, immunohistochemistry, prognosis