上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (7): 1033-.doi: 10.3969/j.issn.1674-8115.2017.07.027

• 综述 • 上一篇    下一篇

ApoE -/- 和LDLR -/- 动脉粥样硬化模型小鼠差异性的研究进展#br#

王建茹，刘 萍   

  1. 上海中医药大学附属龙华医院心内科，上海 200032
  • 出版日期:2017-07-28 发布日期:2017-08-25
  • 通讯作者: 刘萍，电子信箱：liuping23@sina.com
  • 作者简介:王建茹（1988—），男，主治医师，博士生；电子信箱：1016052609@qq.com
  • 基金资助:
    国家自然科学基金（81573739）；上海市科学技术委员会科研计划项目（17140901002）；国家教育部博士点基金（20133107110003）

Advances in differences between ApoE -/- and LDLR -/- atherosclerotic model mice#br#

WANG Jian-ru, LIU Ping   

  1. Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Online:2017-07-28 Published:2017-08-25
  • Supported by:
    National Natural Science Foundation of China, 81573739; Scientific Research Project of Science and Technology Committee of Shanghai Municipality, 17140901002; Doctoral Scientific Fund of the Ministry of Education, China, 20133107110003

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摘要：  动物模型是研究动脉粥样硬化发病机制、病理过程及治疗方法的重要工具。动脉粥样硬化的动物模型主要有鼠、兔、猪、非 人灵长类动物等，其中 ApoE -/- 和 LDLR-/- 小鼠模型是目前使用最为广泛的 2 种动脉粥样硬化动物模型。两者虽然均可形成动脉粥样 硬化的病灶，但在某些方面却存在明显的差异。该文从脂质代谢、斑块形成及病理、淋巴细胞、巨噬细胞、树突状细胞、miRNA 表 达及调控等方面对这 2 种小鼠模型的差异性作一综述。

关键词: 动脉粥样硬化, 动物模型, 载脂蛋白 E, 低密度脂蛋白受体, 基因敲除

Abstract:

Animal models are very important tools to study the pathogenesis, pathology and treatment of atherosclerosis. Animal models for studying atherosclerosis include rodents, rabbits, pigs and nonhuman primates. Among them, ApoE -/- mouse and LDLR-/- mouse are currently the most widely used. They can form atherosclerotic lesions, but in some respects there are significant differences. In this paper, the differences between the two model mice in lipid metabolism, plaque formation and pathology, lymphocytes, macrophages, dendritic cells, microRNA expression and regulation were reviewed.

Key words: atherosclerosis, animal model, apolipoprotein E, low density lipoprotein receptor, gene knockout