上海交通大学学报(医学版) ›› 2017, Vol. 37 ›› Issue (8): 1169-.doi: 10.3969/j.issn.1674-8115.2017.08.024

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小胶质细胞在自发性蛛网膜下腔出血中的激活机制及针对其的 治疗进展

韩硕,吕涛,张晓华   

  1. 上海交通大学 医学院附属仁济医院神经外科,上海  200127
  • 出版日期:2017-08-28 发布日期:2017-09-28
  • 通讯作者: ?张晓华,电子信箱:zxh1969@aliyun.com
  • 作者简介:?韩硕(1993—),男,博士生;电子信箱:911390201@qq.com
  • 基金资助:
    国家自然科学基金(81471333)

Activation mechanism and therapeutic use of microglia in subarachnoid hemorrhage#br#

HAN Shuo, LÜ Tao, ZHANG Xiao-hua   

  1. Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2017-08-28 Published:2017-09-28
  • Supported by:
    National Natural Science Foundation of China, 81471333

摘要: 蛛网膜下腔出血(SAH)发生后,小胶质细胞活化并参与早期脑损伤和迟发性脑缺血的病理生理过程,决定SAH 患者的转 归。众多研究表明,小胶质细胞在 SAH 中有不同的分型和激活通路,功能也不尽一致。因此,干预 SAH 后小胶质细胞的激活过程或 减少释放细胞毒性代谢物,对于改善 SAH 患者预后具有重要意义。

关键词:  小胶质细胞, 蛛网膜下腔出血, 脑血管痉挛, 激活机制

Abstract: Microglia are activated and involve in the pathological and physiological processes of early brain injury and delayed cerebral ischemia after subarachnoid hemorrhage, thus impact the outcome of patients. Numerous studies have shown that microglia have different typings, signaling pathways, and functions. Interference with microglial activation or reduction of cytotoxic metabolites is important for improving the prognosis of SAH patients.

Key words: microglia, subarachnoid hemorrhage, vasospasm, activation mechanism