上海交通大学学报(医学版) ›› 2017, Vol. 37 ›› Issue (8): 1174-.doi: 10.3969/j.issn.1674-8115.2017.08.025

• 综述 • 上一篇    下一篇

代谢组学在急性肾损伤诊断与治疗中的应用

平凤 1,郭勇 2,刘玉静 2,曹永梅 2,李颖川 1   

  1. 上海交通大学附属第六人民医院麻醉科,上海 200233
  • 出版日期:2017-08-28 发布日期:2017-09-28
  • 通讯作者: 李颖川,电子信箱:dr.yingchuan.li@gmail.com
  • 作者简介:平凤(1991—),女,硕士生;电子信箱:pingfeng@sjtu.edu.cn
  • 基金资助:
    上海市卫生计生系统重要薄弱学科建设计划(2015ZB0103)

Application of metabonomics in the diagnosis and treatment of acute kidney injury#br#

PING Feng1, GUO Yong2, LIU Yu-jing2, CAO Yong-mei2, LI Ying-chuan1   

  1. Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233,China
  • Online:2017-08-28 Published:2017-09-28
  • Supported by:
    Shanghai Municipal Commission of Health and Family Planning Foundation for Key Developing Disciplines, 2015ZB0103

摘要:  急性肾损伤(AKI)是指由多种病因、多种危险因素引起的肾功能快速下降的复杂的临床综合征。代谢组学是组学领域的最 新学科,是指采取非靶向测量、定量分析一个给定的细胞、组织、器官、生物体液中所有小分子代谢物的含量。由于相较于基因组 学、转录组学和蛋白质组学,代谢组学具有代谢产物种类少、预测发生的生物过程最准确、样本容易获得的优势,因此非常适用于确 定 AKI 早期诊断的新标志、鉴定 AKI 中可能存在的异常的代谢途径、探索药物治疗的新靶点以及提供个体化精准医疗。

关键词:  急性肾损伤, 代谢组学, 生物标志物, 代谢途径

Abstract: Acute kidney injury (AKI) is the complex clinical syndrome attributed to multiple causes and risk factors, which is characterized by an abrupt loss of renal function. Metabonomics, recently advances in the field of omics, is the nontargeted measurement of all of the low-molecularweight compounds that appear in a particular cell, tissue, organ or biofluid in a living organism. Compared to genomics, transcriptomics and proteomics, metabonomics has its unique advantages, including fewer metabolites than genes, transcripts and proteins, the most accurate predictors of the signature of the actual processes, easy access to biofluids. Thus, metabonomics makes it possible to find new biomarkers for AKI on early diagnosis, identifying new metabolic pathways, finding new targets for drug therapy and individual medical treatment.

Key words: acute kidney injury, metabonomics, biomarkers, metabolic pathways