上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (9): 1261-.doi: 10.3969/j.issn.1674-8115.2017.09.012

• 综述 • 上一篇    下一篇

ACE2/Apelin 信号在血管自噬调控和高血压发病中的作用#br#

张艳，程玉文，钟久昌   

  1. 上海市高血压研究所，上海交通大学 医学院附属瑞金医院医学基因组学国家重点实验室，上海  200025
  • 出版日期:2017-09-28 发布日期:2017-10-10
  • 通讯作者: 钟久昌，电子信箱 : jiuchangzhong@aliyun.com
  • 作者简介:?张艳（1989—），女，博士生；电子信箱：308070790@qq.com
  • 基金资助:
    国家自然科学基金（81370362，81770253）；国家重大研究计划资助项目（91339108）；国家重点基础研究发展计划（2014CB542300）；上海市教育 委员会高峰高原学科建设计划（20152509）

Effects of ACE2/Apelin signaling on vascular autophagy regulation and  hypertension pathogenesis#br#

ZHANG Yan, CHENG Yu-wen, ZHONG Jiu-chang   

  1. Shanghai Institute of Hypertension; State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2017-09-28 Published:2017-10-10
  • Supported by:
    National Natural Science Foundation of China, 81370362, 81770253; National Major Research Plan Training Program, 91339108; National Basic Research Program of China, 2014CB542300; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152509

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摘要： 自噬在维持正常血管结构功能中提供保护功效，但过度自噬可能导致高血压病等血管疾病的发病。血管自噬失衡参与高血压 血管重构损伤的发生和发展，且与 ACE2/Apelin 信号表达或活性异常密切相关。该文主要对 ACE2/Apelin 信号参与血管自噬调控及其 在高血压发病过程中的作用作一综述。

关键词: 高血压, 肾素—血管紧张素系统, 自噬, 血管紧张素Ⅱ

Abstract:

 Autophagy provides protective effects on the maintenance of normal vascular structure and function. However, an overactivation of autophagy contributes to the pathogenesis of hypertension and other vascular diseases. The imbalance of vascular autophagy is involved in the occurrence and development of hypertensive vascular remodeling and injury, which is closely related to abnormal expression or activity of ACE2/Apelin signaling. This review will focus on the latest advancement and regulatory roles of ACE2/Apelin signaling in vascular autophagy and the pathogenesis of hypertension.

Key words: hypertension, renin-angiotensin system, autophagy, angiotensin Ⅱ