上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (11): 1542-.doi: 10.3969/j.issn.1674-8115.2017.11.016

• 论著（临床研究） • 上一篇    下一篇

骨盆软骨肉瘤临床特点和预后因素分析

赵起悟，王继壮，张伟滨，沈宇辉，万荣   

  1. 上海交通大学 医学院附属瑞金医院骨科，上海  200025
  • 出版日期:2017-11-28 发布日期:2018-01-10
  • 通讯作者: 万荣，电子信箱：rongww@hotmail.com
  • 作者简介:赵起悟（1993—），男，硕士生，电子信箱：zhaoqiwu@sjtu.edu.cn
  • 基金资助:
     上海市教育委员会高峰高原学科建设计划（20152204）

Clinical characteristics and prognostic factors of pelvic chondrosarcoma#br#

ZHAO Qi-wu, WANG Ji-zhuang, ZHANG Wei-bin, SHEN Yu-hui, WAN Rong   

  1. Department of Orthopaedic, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2017-11-28 Published:2018-01-10
  • Supported by:
    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152204

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摘要：  目的 · 分析骨盆软骨肉瘤临床特点和预后因素，为临床诊治提供参考。方法 · 收集73 例软骨肉瘤患者病例资料，其中24 例为骨盆软骨肉瘤。总结骨盆软骨肉瘤的临床特点，分析其预后因素。结果 · 24 例骨盆软骨肉瘤患者中，男女比1.4:1，中位年龄 43.5 岁。按 Enneking 骨盆肿瘤分区，Ⅰ区 5 例，Ⅱ区 14 例，Ⅲ区 5 例；组织学分级为软骨肉瘤I 级的1 例，Ⅱ级 15 例，Ⅲ级 8 例；组织学类型为普通中央型 17 例，去分化型 3 例，继发型 2 例，黏液型、间质型各 1 例。24 例患者 3、5 和 10 年总生存率分别为 （82.2±8.1） %、（ 77.3±8.9） %、（ 52.4±12.1） %。骨盆软骨肉瘤手术切除后局部复发率 (83.3%) 高于其他部位（34.7%），差异有统计 学意义（P=0.000）；最终接受截肢手术的比例（50.0%）也高于其他部位（20.4%），差异有统计学意义（P=0.000）；但 2 组总生存时 间比较，差异无统计学意义（P=0.216）。 结论 · 骨盆软骨肉瘤局部复发率较高，更易导致截肢；术后较早复发，提示其预后不佳。

关键词: 骨盆软骨肉瘤, 预后因素, 肿瘤复发

Abstract:

Objective · To summarize the clinical characteristics and prognostic factors of pelvic chondrosarcoma.  Methods · A total of 73 cases of chondrosarcoma  were collected, including 24 of pelvic. The clinical characteristics and prognostic factors of pelvic chondrosarcoma were analyzed by statistic methods.  Results · The ratio of men to women was 1.4:1,and the median age is 43.5 years old.  According to the classification of pelvic proposed by Enneking, there were 5 in region Ⅰ , 14 in region Ⅱ , and 5 in region Ⅲ . On histological review, 1 was grade 1, 15 were grade 2 ,and 8 were grade 3. The histologic types included 17 conventional, 3 dedifferentiated, 2 secondary, and 1 mesenchymal. The overall survival rates of pelvic chondrosarcoma were （82.2±8.1） %,（77.3±8.9） % and（52.4±12.1） % for 3, 5 and 10 years respectively. Local recurrence rate of pelvic chondrosarcoma (83.3%) was significantly higher than those of other sites (34.7%)(P=0.000), and the proportion of amputation was significantly higher than the other sites (50.0% vs 20.4%, P=0.000), but there was no significant difference in the overall survival between the two groups (P=0.216).  Conclusion · Pelvic chondrosarcoma have a higher local recurrence rate than the other sites and is tend to result in amputation. Early local recurrence after surgery indicates poor prognosis.

Key words: pelvic chondrosarcoma, prognostic factors, tumor recurrence

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