上海交通大学学报(医学版) ›› 2017, Vol. 37 ›› Issue (12): 1702-.doi: 10.3969/j.issn.1674-8115.2017.12.024

• 综述 • 上一篇    下一篇

肾移植受者肾功能及免疫状态监测与评价研究进展

Olivier VYUNGURA,王祥慧   

  1. 上海交通大学 医学院附属瑞金医院泌尿外科,上海 200025
  • 出版日期:2017-12-28 发布日期:2018-01-10
  • 通讯作者: 王祥慧,电子信箱:wxh@medmail.com.cn
  • 基金资助:
    上海市科学技术委员会项目(10DZ2212000)

Research progress of monitoring and evaluation of immune state and renal function in renal transplant #br# recipients

Olivier VYUNGURA, WANG Xiang-hui   

  1. Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2017-12-28 Published:2018-01-10
  • Supported by:
    Shanghai Municipal Science and Technology Committee Foundation,10DZ2212000

摘要: [ 摘要 ] 肾移植目前已被国际移植领域公认为治疗尿毒症的最有效手段。免疫抑制不足或免疫抑制过度可导致排斥反应、感染、肿瘤及严重药物不良反应,影响移植受者的生存及移植肾的存活。寻找具有更高敏感度和特异度的方法,进行动态监测,尽早发现移植肾功能异常及排斥反应,是移植领域亟待解决的问题。该文对近年来临床上监测和评价肾移植受者肾功能和免疫状态的技术与方法及其研究进展进行综述。

关键词: &ensp, 肾移植;肾功能;免疫监测;生物标志物;排斥反应

Abstract: [Abstract] Renal transplantation is still the most effective treatment for end stage renal disease up to date. Immunosuppression therapy can complicate
the rejection and severe complications if it is used insufficient or excessive, which may lead to poor survival of patients and grafts . Currently and in
the future, discovery of more sensitive biomarkers and better detection methods of allograft rejection and renal function is a major subject of clinical
investigation and transplant medicine. This paper reviews the latest research progress in assessment of immune state and renal function after kidney
transplantation

Key words: ] kidney transplantation, renal function, immunologic monitoring, biomarker, rejection