上海交通大学学报(医学版) ›› 2018, Vol. 38 ›› Issue (1): 108-.doi: 10.3969/j.issn.1674-8115.2018.01.021

• 综述 • 上一篇    下一篇

动脉粥样硬化的疫苗防治策略

薛雨晨,尤纱纱,曹惠敏,何斌   

  1. 上海交通大学 医学院附属新华医院麻醉与重症医学科,上海 200092
  • 出版日期:2018-01-28 发布日期:2018-03-09
  • 通讯作者: ?何斌,电子信箱:hebin@xinhuamed.com.cn。
  • 作者简介:薛雨晨(1995—),女,硕士生;电子信箱:18721034504@163.com。
  • 基金资助:
    国家自然科学基金(81470390);上海市教育委员会高峰高原学科建设计划(20152218);上海申康医院发展中心促进市级医院临床技能与临床创新 三年行动计划(16CR3006A);上海市科学技术委员会科研计划项目(17411954700)

Vaccine strategies in prevention and treatment of atherosclerosis#br#

XUE Yu-chen, YOU Sha-sha, CAO Hui-min, HE Bin   

  1. Department of Anesthesiology and SICU, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2018-01-28 Published:2018-03-09
  • Supported by:
     National Natural Science Foundation of China, 81470390; Shanghai Municipal  Education Commission—Gaofeng Clinical Medicine Grant Support, 20152218; Clinical Research Plan of Shanghai Hospital Development Center, 16CR3006A; Program of  Science and Technology Commission of Shanghai Municipality, 17411954700

摘要: 动脉粥样硬化是动脉壁的免疫炎症性疾病,包括针对多种内源性、外源性抗原的先天性和适应性免疫。同时,多项研究表明 免疫系统在动脉粥样硬化过程中发挥着双重作用。因此,采用免疫调节策略,激活针对相关抗原的免疫反应,有可能改变动脉粥样硬 化的自然进程。胆固醇酯转运蛋白(cholesterol ester transfer protein,CETP)在脂质代谢中发挥重要作用,是治疗动脉粥样硬化的重 要靶点。该文主要围绕 CETP 疫苗,就近年来抗动脉粥样硬化疫苗的研究进展作一综述。

关键词: 动脉粥样硬化, 免疫, 疫苗, 胆固醇酯转运蛋白

Abstract: Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding  to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in  atherosclerosis. Hence, it is conceivable that an immuno-modulatory strategy via active immunization against many of these antigens could potentially alter the natural history of atherosclerosis. Cholesterol ester transfer protein (CETP) plays an important role in lipid metabolism, suggesting it might prevent  atherosclerosis. This review discusses the recent advances of vaccine targeting the development of atherosclerosis, mainly about the CETP targeting vaccines.

Key words: &ensp, atherosclerosis, &ensp, immunization, &ensp, vaccine, &ensp, cholesterol&ensp, ester&ensp, transfer&ensp, protein