上海交通大学学报(医学版) ›› 2018, Vol. 38 ›› Issue (1): 112-.doi: 10.3969/j.issn.1674-8115.2018.01.023

• 综述 • 上一篇    下一篇

B 淋巴细胞在视神经脊髓炎谱系疾病发病中的作用

韩露 1,李梅 2,朱德生 1,李则挚 1,刘明媛 2,管阳太 1   

  1. 1. 上海交通大学  医学院附属仁济医院神经内科,上海 200001;2. 第二军医大学附属长海医院神经内科,上海 200433
  • 出版日期:2018-01-28 发布日期:2018-03-09
  • 通讯作者: ?管阳太,电子信箱:yangtaiguan@sina.com。
  • 作者简介:?韩 露(1990—),女,硕士生;电子信箱:hlkcn1990@163.com。
  • 基金资助:
    国家自然科学基金(81200924,81230027,81401127);上海市卫生和计划生育委员会基金(201440347,20134Y044);上海交通大学医工交叉基金 (YG2016MS48)

Role of B lymphocytes in pathogenesis of neuromyelitis optica spectrum disorder#br#

HAN Lu1, LI Mei2, ZHU De-sheng1, LI Ze-zhi1, LIU Ming-yuan2, GUAN Yang-tai1   

  1. 1. Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China; 2. Department of Neurology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Online:2018-01-28 Published:2018-03-09
  • Supported by:
     National Natural Science Foundations of China, 81200924, 81230027, 81401127; Foundation of Shanghai Municipal Commission of Health and Family  Planning, 201440347, 20134Y044; Shanghai Jiao Tong University Medicine-Engineering Foundation, YG2016MS48

摘要:  视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorder,NMOSD)是以体液免疫介导为主的一类中枢神经系统自身免 疫性疾病谱系,特异性表达水通道蛋白 -4(aquaporin-4,AQP-4)抗体,常以视神经和脊髓受累为主要表现。但临床中 AQP-4 抗体表 达水平与疾病活动度和复发率往往不呈正比,提示其他途径介导了疾病的发生。临床和基础研究中均有许多现象提示B 淋巴细胞在 NMOSD 的发病机制中发挥了重要作用。该文主要对 B 淋巴细胞在 NMOSD 发病机制中的作用进行综述,从 B 淋巴细胞的抗原提呈、 体液免疫、调节性 B 淋巴细胞效应及免疫耐受等角度阐述 B 淋巴细胞介导 NMOSD 的发病过程。

关键词: 视神经脊髓炎谱系疾病, B 淋巴细胞, 发病机制

Abstract:

 The neuromyelitis optica spectrum disorders (NMOSD) are a spectrum of central nervous system autoimmune diseases caused by humoralmediated immunity. NMOSD is characterized by specific expression of aquaporin-4 (AQP-4) antibody and involvement of optic nerve and spinal cord.  However, the expression level of AQP-4 antibody is not directly proportional to disease activity and recurrence rate, suggesting that multiple mechanisms  have been involved in mediating the process of disease. Many evidences of clinical and basic experiments indicated that B lymphocytes play an important  role in the pathogenesis of NMOSD. This paper mainly summarized the role of B lymphocytes in the pathogenesis of NMOSD, including aspects of antigen presentation, humoral immunity, regulatory B cell effect and B cell immune tolerance.

Key words: neuromyelitis&ensp, optica&ensp, spectrum&ensp, disorder, &ensp, B&ensp, lymphocytes, &ensp, pathogenesis