上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (11): 1327-.doi: 10.3969/j.issn.1674-8115.2018.11.010

• 论著·临床研究 • 上一篇    下一篇

多体素磁共振波谱成像在舌癌诊断中的应用及临床价值

王博成 1, 2，朱丹 2，李晓光 3，吴利忠 2，赵江民 2，糜军 1   

  1. 1. 上海交通大学基础医学院，上海 200025；2. 上海交通大学医学院附属第九人民医院影像科，上海 200011；3. 上海交通大学医学院附属第九人民医院口腔颌面外科，上海 200011
  • 出版日期:2018-11-28 发布日期:2018-12-15
  • 通讯作者: 糜军，电子信箱：jmei@sjtu.edu.cn。赵江民，电子信箱：johnmzhao@sjtu.edu.cn。为共同通信作者。
  • 作者简介:王博成（1985—），男，主管技师，硕士生；电子信箱： asakulakira@163.com。
  • 基金资助:
    上海市科学技术委员会科技创新行动计划重点项目（10411953400）

Application and clinical value of multi-voxel magnetic resonance spectroscopy in the diagnosis of tongue carcinoma

WANG Bo-cheng1, 2, ZHU Dan2, LI Xiao-guang3, WU Li-zhong2, ZHAO Jiang-ming2, MEI Jun1   

  1. 1. Shanghai Jiao Tong University College of Basic Medical Sciences, Shanghai 200025, China; 2. Department of Radiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; 3. Department of Oral and Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Online:2018-11-28 Published:2018-12-15
  • Supported by:
    Key Project of Innovation Action Plan of Shanghai Municipal Science and Technology Commission, 10411953400

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摘要： 目的 ·探讨多体素磁共振波谱成像（multi-voxel magnetic resonance spectroscopy，MVMRS）在舌癌诊断中的应用及临床价值。方法 ·回顾性分析 2017年 1—12月间 56例经病理诊断为单侧舌原发鳞状细胞癌（鳞癌）或腺样囊腺癌（腺癌）患者病灶中代谢产物 MVMRS波谱曲线特征。比较鳞癌组或腺癌组肿瘤实质区、环肿瘤区与健侧对照区间表观弥散系数（ apparent diffusion coefficient， ADC）及代谢产物胆碱（ choline，Cho）、肌酸（ creatine，Cr）、胆碱 /肌酸比值（ Cho/Cr）、乳酸 /脂质（ lactate and lipids，LL）信号强度的差异；比较鳞癌组与腺癌组相应区域间 ADC值及代谢产物信号强度的差异；观察 2组各区域内 Cho、LL信号强度与 ADC值的相互关系。结果 ·鳞癌组和腺癌组肿瘤实质区代谢产物 Cho、LL信号强度均高于各自的环肿瘤区和健侧对照区（均 P0.000），而 ADC值则低于各自的环肿瘤区和健侧对照区（均 P0.000）；环肿瘤区的 Cho、LL信号强度和 ADC值介于各自的肿瘤实质区和健侧区之间（均 P0.000）；不同区域 Cr和 Cho/Cr信号强度差异无统计学意义（均 P>0.01）。鳞癌组与腺癌组相应区域间 ADC值、代谢产物信号强度差异无统计学意义（均 P>0.01）。鳞癌肿瘤实质区内 LL峰信号强度与 ADC值呈线性负相关（ P0.000）。结论 · MVMRS可以检测舌癌中肿瘤代谢产物的含量，环肿瘤区内 ADC值和 Cho、LL信号强度的改变可反映出受肿瘤侵犯的程度。

关键词: 多体素磁共振波谱成像, 舌癌, 诊断, 代谢产物

Abstract:

Objective · To determine clinical value of multi-voxel magnetic resonance spectroscopy (MVMRS) in the diagnosis of tongue carcinoma. Methods · A total of 56 cases that were pathologically diagnosed as having unilateral squamous cell carcinoma (SCC) or adenoid cystadenocarcinoma (ACC), January to December 2017, were selected in this retrospective study. The characteristics of metabolic profiles in MVMRS were analyzed. The signals of choline (Cho), creatine (Cr), choline creatine ratio (Cho/Cr), and lactate/lipids (LL) and the apparent diffusion coefficient (ADC) were comparatively analyzed among the tumor parenchymal area, the paratumor area, and the contralateral control area in SCC/ACC group. The above indexes in the relative areas between SCC and ACC were also compared. Moreover, the relationship between the LL or Cho signal intensity with ADC in all the areas of two groups was investigated. Results · Higher Cho and LL signals were observed in the tumor parenchymal areas than those in the paratumor areas and the contralateral control areas in both SCC and ACC groups (P0.000), while ADC values in the tumor parenchymal areas were obviously lower (P0.000). Cho and LL signal intensities and ADC values in the paratumor areas were between the tumor parenchymal areas and contralateral control areas in both groups (P0.000). However, no significant difference among the areas in Cr or Cho/Cr signal was found (P>0.01). There was no significant difference between SCC and ACC groups in the relative areas, either (P>0.01). The signal intensity of LL in the tumor parenchymal area in SCC group was negatively linearly correlated with the ADC value (P0.000). Conclusion · MVMRS can detect the content of metabolites in tongue carcinoma, and LL and Cho signal intensities with ADC value can reflect the degree of tumor invasion in the paratumor areas.

Key words: multi-voxel magnetic resonance spectroscopy (MVMRS), tongue carcinoma, diagnosis, metabolite

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