上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (4): 383-.doi: 10.3969/j.issn.1674-8115.2019.04.009

• 论著·临床研究 • 上一篇    下一篇

月经相关性偏头痛患者的维生素 D水平研究

袁欣 1，蒋伟青 1，任潇 1，刘晨 2，王永刚 1   

  1. 1. 上海交通大学医学院附属仁济医院神经内科，上海 200127；2. 郑州大学第一附属医院神经内科，郑州 450052
  • 出版日期:2019-04-28 发布日期:2019-05-23
  • 通讯作者: 王永刚，电子信箱：wangyg@shsmu.edu.cn。
  • 作者简介:袁欣（1993—），女，硕士生；电子信箱： 13262627180@163.com。
  • 基金资助:
    国家自然科学基金（31770800，81571329，81271140）；上海市教育委员会高峰高原学科建设计划（ 20161414）

Vitamin D level in patients with menstrually related migraine

YUAN Xin1, JIANG Wei-qing1, REN Xiao1, LIU Chen2, WANG Yong-gang1   

  1. 1. Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2. Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  • Online:2019-04-28 Published:2019-05-23
  • Supported by:
    National Natural Science Foundation of China, 31770800, 81571329, 81271140; Shanghai Municipal Education Commission—GaoFeng Clinical Medicine Support, 20161414)。

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摘要： 目的 ·比较月经相关性偏头痛患者与非月经性偏头痛患者维生素 D水平的差异。方法 ·纳入 2017年 6月— 2018年 6月于上海交通大学附属仁济医院就诊的符合月经相关性偏头痛患者 100例为病例组，匹配 100例非月经性偏头痛患者为对照组。采集患者临床信息及检测血清维生素 D水平。采用单因素分析比较组间临床资料的差异，采用 Logistic回归模型分析月经相关性偏头痛与维生素 D水平的关系。结果 ·与对照组相比，病例组维生素 D水平较低 [（13.48±5.02）ng/mL vs（14.93±4.94）ng/mL]，组间差异有统计学意义（ P0.042）。其余临床资料的组间差异均无统计学意义（均 P>0.05）。Logistic回归分析结果显示，维生素 D低于 10 ng/mL的患者是高于 20 ng/mL的患者发生月经相关性偏头痛的 3.656倍（OR3.656，95%CI 1.382～ 9.672，P0.009）。另外，偏头痛发生于月经前与月经中的患者在临床特点及维生素 D水平等方面的差异均无统计学意义（均 P>0.05）。结论 ·低维生素 D水平可能与月经相关性偏头痛发生相关，但与偏头痛发生于月经前或月经中无关。

关键词: 偏头痛, 月经相关, 维生素 D

Abstract:

Objective · To compare vitamin D levels in the patients with menstrually related migraine and those with non-menstrual migraine. Methods · A total of 100 patients with menstrually related migraine were enrolled as case group, and 100 patients with non-menstrual migraine were matched as control group in Renji Hospital, Shanghai Jiao Tong University School of Medicine, June 2017 to June 2018. The patients’ information was collected and serum vitamin D levels were measured. Univariate analysis was performed to analyze the differences between the groups, and Logistic regression model was performed to analyze the relationship between menstrually related migraine and vitamin D levels. Results · Vitamin D levels were lower in case group than those in control group [(13.48±5.02) ng/mL vs (14.93±4.94) ng/mL, P0.042]. There were no statistically significant differences in other indexes between the groups (P>0.05). Logistic regression analysis showed that the patients with vitamin D less than 10 ng/mL were more likely to have menstrually related migraine than those with vitamin D more than 20 ng/ml (OR3.656, 95% CI 1.382-9.672，P0.009). In addition, there were no statistically significant differences in clinical characteristics and vitamin D levels between the patients with migraine occurring in premenstrual period and menstrual period (P>0.05). Conclusion · Low vitamin D levels may be associated with menstrually related migraine, but not with its occurrence in premenstrual or menstrual period. [Key words]migraine; menstrually related; vitamin D

Key words: migraine, menstrually related, vitamin D

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