上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (4): 428-.doi: 10.3969/j.issn.1674-8115.2019.04.018

• 综述 • 上一篇    下一篇

氯胺酮及内源性大麻素系统在快速抗抑郁中的作用研究进展

姚亚民，方贻儒   

  1. 上海交通大学医学院附属精神卫生中心心境障碍科，上海 200030
  • 出版日期:2019-04-28 发布日期:2019-05-23
  • 通讯作者: 方贻儒，电子信箱：yirufang@aliyun.com。
  • 作者简介:姚亚民（1982—），男，博士生；电子信箱： 947874367@qq.com。
  • 基金资助:
    国家重点研究发展计划 (2016YFC1307100)；国家自然科学基金（ 81771465）；“十二五”国家重点研发计划 (2012BAI01B00)

Action of ketamine and endocannabinoid system in rapid anti-depression therapy

YAO Ya-min, FANG Yi-ru   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
  • Online:2019-04-28 Published:2019-05-23
  • Supported by:
    National Key R&D Program of China, 2016YFC1307100; National Natural Science Foundation of China, 81771465; The “12th Five-year Plan” of National Key Technology R&D Program， 2012BAI01B00)。

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摘要： 抑郁症是现代社会一类常见且严重的情感障碍疾病，其进展后期常伴随有自杀意念及自杀行为，给社会、家庭带来沉重负担。抗抑郁药物治疗对一部分重度抑郁症患者无明显疗效，这一类抑郁症又称为耐药性抑郁症 (treatment resistant depression，TRD)。有研究报道了氯胺酮的快速及长效的抗抑郁作用，对 TRD亦有明显的治疗效果。大麻中的主要活性物质 Δ 9-四氢大麻酚也可通过作用于脑内大麻素受体发挥快速抗抑郁作用，这 2种中枢神经兴奋剂都具有明显的不良反应，属于严格管控的精神活性物质。该文结合近年来相关研究就氯胺酮及内源性大麻素系统快速抗抑郁作用作一综述。

关键词: 氯胺酮, 内源性大麻素系统, 抑郁症, &, Delta, 9-四氢大麻酚, 脑源性神经生长因子, 哺乳动物雷帕霉素靶蛋白信号通路, N-甲基 -D-天冬氨酸受体

Abstract:

Major depression disorder (MDD) is a common but serious affective disorder in modern society. Suicide idea and suicide behaviour inducedMDD during its later stage put a heavy burden on society and family. Anti-depression drugs lack efficiency in treating a portion of MDD patients. This is referred to as treatment resistant depression (TRD). A study reported the rapid onset and long lasting anti-depression effect of ketamine, which also come into effect in TRD patients. Δ9-Tetrahydrocannabinol is the active substance of marijuana, which also exerts rapid anti-depression effect via targeting at brain cannabinoid receptors. The two central nerve system stimulants belonging to the tightly controlled psychoactive substances have obvious adverse effects. This article summarizes the action of ketamine and endocannabinoid system in rapid anti-depression therapy in recent researches. [Key words]ketamine; endocannabinoid system; major depression disorder; Δ9-tetrahydrocannabinol (Δ9-THC); brain derived neurontrophic factor (BDNF); mammalian target of rapamycin (mTOR) pathway; N-methyl-D-aspartate (NMDA) receptor

Key words: ketamine, endocannabinoid system, major depression disorder, &, Delta, 9-tetrahydrocannabinol (&, Delta, 9-THC), brain derived neurontrophic factor (BDNF), mammalian target of rapamycin (mTOR) pathway, N-methyl-D-aspartate (NMDA) receptor

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