上海交通大学学报(医学版) ›› 2019, Vol. 39 ›› Issue (6): 678-.doi: 10.3969/j.issn.1674-8115.2019.06.019

• 综述 • 上一篇    下一篇

代谢性疾病中胆汁酸水平变化及相关治疗策略

况俊良,郑晓皎,赵爱华,贾伟   

  1. 上海交通大学附属第六人民医院转化医学中心,上海 200233
  • 出版日期:2019-06-28 发布日期:2019-07-26
  • 通讯作者: 贾伟,电子信箱:weijia@sjtu.edu.cn。
  • 作者简介:况俊良(1994—),男,硕士生;电子信箱: sapphirekjl@163.com。
  • 基金资助:
    国家自然科学基金(81772530)

Alterations in bile acid levels in metabolic diseases and related treatment strategies

KUANG Jun-liang, ZHENG Xiao-jiao, ZHAO Ai-hua, JIA Wei   

  1. Center for Translational Medicine, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2019-06-28 Published:2019-07-26
  • Supported by:
    National Natural Science Foundation of China, 81772530)。

摘要: 胆汁酸作为一种信号分子可以特异性地与胆汁酸受体(如法尼醇 X受体、 G蛋白偶联胆汁酸受体 1)结合介导一系列生物调节反应。近年发现,胆汁酸在调节糖代谢、脂质代谢和能量代谢中扮演着十分重要的角色。在代谢性疾病的发生发展过程中,也常伴随着胆汁酸谱以及受体的改变。基于胆汁酸在代谢性疾病中的重要性,未来其可能成为临床诊断、预测、评价治疗效果的潜在生物标志物。该文对胆汁酸与代谢性疾病关系以及基于调节胆汁酸代谢治疗代谢性疾病进行综述。

关键词: 胆汁酸, 代谢性疾病, 法尼醇 X受体, G蛋白偶联胆汁酸受体 1, 生物标志物

Abstract: Bile acid as a signaling molecule can specifically bind to bile acid receptors (such as farnesoid X receptor and G-protein-coupled bile acid receptor) to mediate a series of biological regulation reactions. In recent years, it has been found that bile acids are widely involved in glucose metabolism, lipid metabolism and energy metabolism. The development of metabolic diseases is usually accompaniedthe changes of bile acid profiles and receptors, and thus bile acids may be applied as potential biomarkers for clinical diagnosis, prediction, and evaluation of therapeutic effects. This article reviews the relationship between bile acids and metabolic diseases, and the treatment of metabolic diseases based on the regulation of bile acid metabolism.

Key words: bile acid, metabolic disease, farnesoid X receptor (FXR), G-protein-coupled bile acid receptor 1, biomarker

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