上海交通大学学报(医学版) ›› 2019, Vol. 39 ›› Issue (7): 795-.doi: 10.3969/j.issn.1674-8115.2019.07.019

• 综述 • 上一篇    下一篇

精神分裂症患者认知功能的神经免疫机制及非典型抗精神病 药物对其影响的研究进展

王丹丹,张晨   

  1. 上海交通大学医学院附属精神卫生中心生化研究室,上海 200030
  • 出版日期:2019-07-28 发布日期:2019-08-26
  • 通讯作者: 张晨,电子信箱:zhangchen645@gmail.com。
  • 作者简介:王丹丹(1994—),女,硕士生;电子信箱: wangdan_630@163.com。
  • 基金资助:
    国家自然科学基金(81471358);上海市科学技术委员会西医引导类项目(14411969000);上海市教育委员会高峰高原学科建设计划(20152530);上海市卫生与计划生育委员会科研项目(201540029)

Research progress of neuroimmune mechanisms of cognitive function in schizophrenia and effect of atypical antipsychotic drugs on it

WANG Dan-dan, ZHANG Chen   

  1. Department of Biochemistry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2019-07-28 Published:2019-08-26
  • Supported by:
    National Nature Science Foundation of China, 81471358;Western Medicine Guide Project of Shanghai Municipal Commission of Science and Technology, 14411969000; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20152530; Foundation of Shanghai Municipal Commission of Health and Family Planning, 201540029

摘要: 非典型抗精神病药物克服传统抗精神病药物严重的泌乳素升高和锥体外系不良反应,成为目前精神科的一线用药。研究发现非典型抗精神病药物可调节患者的免疫炎症状态,影响患者的认知功能,而越来越多证据表明神经免疫紊乱可能损害患者的认知功能。该文就精神分裂症患者认知功能的神经免疫机制及非典型抗精神病药物对其影响的研究进展作一综述。

关键词: 抗精神病药物, 认知功能, 精神分裂症, 神经免疫

Abstract:

Atypical antipsychotic drugs have overcome the serious prolactin elevation and extrapyramidal symptoms of typical antipsychotic drugs, and become the first-line treatment for psychiatry. Studies have found that atypical antipsychotic drugs can modulate the immune inflammatory state of patients and affect their cognitive function, and there is increasing evidence suggesting that neuroimmune disorders may impair cognitive function in schizophrenia. This article reviews the progress of neuroimmune mechanisms of cognitive function in schizophrenia and the effect of atypical antipsychotic drugs on it.

Key words: antipsychotics, cognitive function, schizophrenia, neuroimmune

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