上海交通大学学报(医学版) ›› 2019, Vol. 39 ›› Issue (8): 914-.doi: 10.3969/j.issn.1674-8115.2019.08.018

• 综述 • 上一篇    下一篇

抑郁症的遗传学研究进展

余玲芳,张晨   

  1. 上海交通大学医学院附属精神卫生中心生化药理研究室,上海 200030
  • 出版日期:2019-08-28 发布日期:2019-09-23
  • 通讯作者: 张晨,电子信箱:zhangchen645@gmail.com。
  • 作者简介:余玲芳(1994—),女,硕士生;电子信箱: yulingfang1222@163.com。
  • 基金资助:
    国家自然科学基金(81471358);上海市科学技术委员会西医引导类项目(14411969000);上海市教育委员会高峰高原学科建设计划(20152530);上海市卫生与计划生育委员会科研项目(201540029)

Genetic research progress of depression

YU Ling-fang, ZHANG Chen   

  1. Biochemical Pharmacology Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2019-08-28 Published:2019-09-23
  • Supported by:
    National Natural Science Foundation of China, 81471358;Western Medicine Guide Project of Shanghai Municipal Commission of Science and Technology; Shanghai Municipal Education Commission— Gaofeng Clinical Medicine Support, 20152530; Foundation of Shanghai Municipal Commission of Health and Family Planning, 201540029

摘要: 抑郁症作为常见精神障碍,给患者造成了极大的负担。目前,人们对抑郁症遗传机制的理解远不如精神分裂症、双相障碍等其他常见精神障碍透彻。近年来,随着临床样本量的不断积累以及研究方法与技术的进步,抑郁症的遗传学研究取得了一定的进展。该文从抑郁症的候选基因、常见变异位点、罕见变异位点以及染色体结构变异等方面对该病的遗传学研究进展作一综述。

关键词: 抑郁症, 遗传学, 研究进展

Abstract:

Depression is a common mental disorder and causes great disease burden. To date peoples understanding of genetic mechanisms of depression is lagging far behind that of other psychiatric disorders such as schizophrenia and bipolar disorder. Recently, with the accumulation of clinical samples and the advances of methodology and technology, certain progress in genetics of depression has been made. This review summarizes the genetic research progress in candidate genes, common variants, rare variants and chromosome structure variations of depression.

Key words: depression, genetics, research progress

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