上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (12): 1416-.doi: 10.3969/j.issn.1674-8115.2019.12.012

• 论著·临床研究 • 上一篇    下一篇

正念干预对苯丙胺类物质使用障碍者的影响

张佳婷1*，张靓颖1*，杜哲一1，李 军2，吕朝晖2，杜 江1   

  1. 上海交通大学医学院附属精神卫生中心，上海200030；2. 上海市高境强制隔离戒毒所，上海201900
  • 出版日期:2019-12-28 发布日期:2020-02-06
  • 通讯作者: 杜 江，电子信箱：dujiangdou@163.com。
  • 作者简介:张佳婷（1982—），女，学士；电子信箱：zjtzyyx@163.com。张靓颖（1994—），女，硕士；电子信箱：jingying_zhang77@163.com。*为共同第一作者。
  • 基金资助:
    国家自然科学基金（81871045）；上海市科学技术委员会项目（19411969200）

Effect of mindfulness-based intervention on functional connectivity of resting state electroencephalogram of amphetamine-type stimulants patients

ZHANG Jia-ting, ZHANG Jing-ying, DU Zhe-yi, LI Jun, Lü Chao-hui, DU Jiang   

  1. 1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Shanghai Gaojing Drug Rehabilitation Center, Shanghai 201900, China
  • Online:2019-12-28 Published:2020-02-06
  • Supported by:
    National Natural Science Foundation of China, 81871045; Project of Science and Technology Commission of Shanghai Municipality, 19411969200

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摘要： 目的·探索正念干预对苯丙胺类物质使用障碍者的作用机制。方法·选取上海市某强制隔离戒毒所苯丙胺类物质使用障碍者40名，随机分成对照组与干预组。对照组仅接受常规治疗，干预组除常规治疗外增加正念干预。分别测量干预前后的静息态脑电及正念觉知注意力。结果·与对照组比较，干预组的正念觉知注意力有改善，睁眼状态下β频段额叶电极F4与F5脑电功能连接增强，冥想状态下顶叶电极P7与枕叶电极O2脑电功能连接增强，差异均有统计学意义（P0.000）。干预组顶枕叶的脑电功能连接增强与其正念觉知注意力得分具有相关性（P0.000）。结论·正念干预能增加苯丙胺使用障碍者正念觉知注意力，并增强部分额叶、顶枕叶脑电功能连接。

关键词: 苯丙胺, 物质使用障碍, 正念干预, 脑电, 功能连接

Abstract:

Objective · To test the mechanism of mindfulness-based intervention in patients with amphetamine-types stimulants disorders. Methods · Forty participants a drug rehabilitation center in Shanghai who had amphetamine-type stimulants disorders were enrolled in this randomized controlled trial and randomly divided into either the intervention group or control group. The control group only received the normal treatment, while the intervention group received mindfulness-based intervention as well as normal treatment. Resting state electroencephalogram and mindfulness attention awareness were assessed before and after the intervention. Results · Compared with the control group, the scores of mindfulness attention awareness improved significantly in the intervention group (P0.000), and functional connectivity of frontal cortex (F4 and F5) under the eye-open state and parietal-occipital cortex (P7 and O2) under the mindfulness state increased significantly in the intervention group in β oscillations (P0.000). Moreover, the functional connectivity of parietal-occipital cortex was significantly correlated with the mindfulness attention awareness scores in the intervention group (P0.000). Conclusion · Mindfulness-based intervention is effective in improving the mindfulness attention awareness and increasing the electroencephalogram functional connectivity of partial frontal and parietal-occipital cortex for patients with amphetamine-type stimulants disorders.

Key words: amphetamine-type stimulants, substance disorders, mindfulness-based intervention, electroencephalogram, functional connectivity