上海交通大学学报(医学版) ›› 2019, Vol. 39 ›› Issue (12): 1477-.doi: 10.3969/j.issn.1674-8115.2019.12.023

• 综述 • 上一篇    

重复经颅磁刺激在强迫症治疗中的应用

李璞玉,王 振   

  1. 上海交通大学医学院附属精神卫生中心,上海200030
  • 出版日期:2019-12-28 发布日期:2020-02-06
  • 通讯作者: 王 振,电子信箱:wangzhen@smhc.org.cn。
  • 作者简介:李璞玉(1995—),女,硕士生;电子信箱:Lipy81@163.com。
  • 基金资助:
    上海市级医院新兴前沿技术联合攻关项目(SHDC12018115),上海市卫生计生系统优秀学科带头人培养计划(2017BR058)

Application of repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder

LI Pu-yu, WANG Zhen   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2019-12-28 Published:2020-02-06
  • Supported by:
    Emerging Advanced Technology Joint Research Project ConductedMunicipal Hospitals in Shanghai, SHDC2018115; Shanghai Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines, 2017BR058

摘要: 目前,有相当比例的强迫症患者通过药物治疗和心理治疗仍无法获得有效缓解,研究者们把目光转向新的物理治疗方向,特别是将重复经颅磁刺激作为难治性强迫症的辅助治疗手段。重复经颅磁刺激是一种非侵入性神经刺激技术,目前已经有不少研究结果证明其治疗强迫症有效,但在刺激靶点、参数设置等的选择上学界也存在争议。该文系统梳理了重复经颅磁刺激在治疗强迫症中的应用,并讨论了目前治疗中存在的不足,由此提出下一步的发展方向,以期推进临床治疗相关进展。

关键词: 重复经颅磁刺激, 强迫症, 辅助运动区, 背外侧前额叶皮质, 眶额回

Abstract: At present, a considerable proportion of patients with obsessive-compulsive disorder (OCD) cannot be effectively relievedstandard drug and psychotherapy, so researchers have turned their attention to new directions of physiotherapy. Repetitive transcranial magnetic stimulation (rTMS), as an adjuvant therapy for refractory OCD, is a non-invasive nerve stimulation technique. Many studies have shown that rTMS is effective in the treatment of OCD. However, there were also disputes in the selection of stimulation targets, parameter settings and so on. This article systematically combs the setting and application of standard rTMS in the treatment of OCD, and comprehensive therapeutic effect of rTMS, and then discusses the deficiency of treatment so far, into put forward the future development direction and promote clinical treatment progress.

Key words: repetitive transcranial magnetic stimulation (rTMS), obsessive-compulsive disorder (OCD), accessory motor area (SMA), dorsolateral prefrontal cortex(DLPFC), orbital frontal cortex (OFC)