上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (06): 820-827.doi: 10.3969/j.issn.1674-8115.2020.06.018

• 论著·临床研究 • 上一篇    

精神分裂症患者语义及句法加工异常的事件相关电位研究

杨 乔1,唐莺莹2,钱禛颖2,杨福中1,乔 屹1,盛建华1#,陆光华3#   

  1. 1. 上海交通大学医学院附属精神卫生中心临床四科,上海 200030;2. 上海交通大学医学院附属精神卫生中心脑电影像研究室,上海 200030;3. 上海交通大学医学院附属精神卫生中心老年二科,上海 200030
  • 出版日期:2020-06-28 发布日期:2020-08-11
  • 通讯作者: 盛建华,电子信箱:shengjianhua66@163.com。陆光华,电子信箱:lghzyy@126.com。#为共同通信作者。
  • 作者简介:杨 乔(1995—),女,硕士生;电子信箱:1448498841@qq.com。
  • 基金资助:
    上海市卫生和计划生育委员会卫生行业临床研究专项(201840269);上海市科学技术委员会西医引导类课题(17411969900);国家临床重点专科-上海市精神卫生中心(卫生部医政司2011-873)。

Abnormal semantic and syntactic processing in patients with schizophrenia: an event-related potential study

YANG Qiao1, TANG Ying-ying2, QIAN Zhen-ying2, YANG Fu-zhong1, QIAO Yi1, SHENG Jian-hua1#, LU Guang-hua3#   

  1. 1. The Fourth Department of Clinical Medicine, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Electroencephalography and Brain Imaging Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 3. The Second Department of Geriatrics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2020-06-28 Published:2020-08-11
  • Supported by:
    Health Profession Clinical Research Funds of Shanghai Municipal Commission of Health and Family Planning (201840269); Western Medicine Guidance Project of Shanghai Science and Technology Commission (17411969900); National Key Clinical Discipline at Shanghai Mental Health Center (OMA-MH 2011-873).

摘要: 目的·探究伴思维形式障碍(formal thought disorder,FTD)的精神分裂症(schizophrenia,SZ)患者、不伴FTD的SZ患者、遗传高危被试及健康对照者在语言加工时事件相关电位中N400、P600成分的差异。方法·选择于上海交通大学医学院附属精神卫生中心住院的伴FTD的SZ患者30例及不伴FTD的SZ患者29例、遗传高危被试(SZ患者的一级亲属)22例及健康对照者31名作为研究对象。要求上述被试完成4种句子加工任务(语义和句法均正确;语义错误,句法正确;句法错误,语义正确;语义和句法均错误),同时记录脑电数据。采用重复测量方差分析比较4组被试的反应正确率及N400、P600成分的波幅和潜伏期的差异。结果·与健康对照者比较,伴FTD的SZ患者反应正确率降低(P=0.000)。伴FTD的SZ患者未诱发显著的N400成分,其N400波幅与健康对照者比较差异有统计学意义(P=0.003)。4组被试均诱发了P600成分,语义、句法和组别之间存在显著的交互作用(P=0.022);进一步分析发现,伴FTD的SZ患者与不伴FTD的SZ患者P600波幅在句法正确和句法错误时差异无统计学意义;伴FTD的SZ患者P600波幅在语义正确和语义错误时差异无统计学意义,其他3组语义正确条件时的P600波幅大于语义错误时的P600波幅。结论·SZ患者在语义加工水平神经活动异常,伴FTD的SZ患者语义和句法加工均受到损害。

关键词: 精神分裂症, 事件相关电位, N400, P600, 语义加工, 句法加工

Abstract: Objective · To explore the differences of event-related potential components (N400 and P600) in response to language processing between schizophrenia (SZ) patients with formal thought disorder (FTD), SZ patients without FTD, genetic high-risk subjects and healthy controls (HC). Methods · Thirty SZ patients with FTD (SZ-FTD group) and 29 SZ patients without FTD (SZ-nFTD group), who were hospitalized in Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 22 subjects at genetic high risk who were first degree relatives of SZ patients, and 31 healthy controls (HC) were recruited. Four different types of sentences (syntactically and semantically correct, syntactically correct but semantically incorrect, syntactically incorrect but semantically correct, and syntactically and semantically incorrect) were presented to the four groups respectively with electroencephalogram recording. Repeated measurement analysis of variance was used to compare the response accuracy of the four groups and to analyze the differences in the amplitude and latency of N400 and P600 components in response to each kind of sentence among the four groups. Results · SZ-FTD group showed a lower accuracy rate compared with the HC group (P=0.000). Compared with the HC group, N400 amplitude in SZ-FTD group was lower in statistically significance (P=0.003), while SZ-FTD group did not show a prominent N400 component. P600 component was well evoked in four groups, and there was an interaction between semantics, syntax and group (P=0.022). By further analysis, neither SZ-FTD nor SZ-nFTD group showed significant differences in P600 amplitudes evoked by syntactically correct and syntactically incorrect sentences. There was no significant difference in P600 amplitudes evoked by semantically correct and incorrect sentences in SZ-FTD group, whereas P600 amplitudes evoked by semantically correct sentences were greater than those evoked by semantically incorrect ones in the other three groups. Conclusion · Neural activity is impaired during semantic processing in SZ. In particular, SZ-FTD patients have impairments in both semantic and syntactic processing.

Key words: schizophrenia (SZ), event-related potential (ERP), N400, P600, semantic processing, syntactic processing

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