上海交通大学学报(医学版) ›› 2021, Vol. 41 ›› Issue (2): 228-232.doi: 10.3969/j.issn.1674-8115.2021.02.016

• 综述 • 上一篇    

原位生物打印的研究进展与前景

李文韬(), 王金武()   

  1. 上海交通大学医学院附属第九人民医院骨科,上海 200011
  • 收稿日期:2020-02-26 出版日期:2021-02-28 发布日期:2021-03-11
  • 通讯作者: 王金武 E-mail:li_wentao@sjtu.edu.cn;Jinwu_wang@163.com
  • 作者简介:李文韬(1996—),男,硕士生;电子信箱:li_wentao@sjtu.edu.cn
  • 基金资助:
    国家重点研发计划(2018YFB1105600);国家自然科学基金(81572156);上海市科学技术委员会项目(19XD1434200);上海市教育委员会高峰高原学科建设计划(20152224)

Progress and prospect of in situ bioprinting

Wen-tao LI(), Jin-wu WANG()   

  1. Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Received:2020-02-26 Online:2021-02-28 Published:2021-03-11
  • Contact: Jin-wu WANG E-mail:li_wentao@sjtu.edu.cn;Jinwu_wang@163.com
  • Supported by:
    National Key Research and Development Program of China(2018YFB1105600);National Natural Science Foundation of China(81572156);Project of Science and Technology Commission of Shanghai Municipality(19XD1434200);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152224)

摘要:

生物打印是一种新兴的生物制造技术,推动了许多创新并为再生医疗开辟了新途径。生物打印的目的是在体外制造移植物,然后将其植入体内,然而一直以来离体组织的培养及血管化都存在难以彻底解决的问题。为了解决这一难题,研究者们提出了原位生物打印的概念,将组织直接打印在受伤或缺损的部位,利用体内的天然细胞微环境使打印组织成熟。该文对原位生物打印的技术、优势、应用领域、发展方向等进行综述。

关键词: 原位生物打印, 组织再生, 生物墨水

Abstract:

Bioprinting is a new biological manufacturing technology, which opens up new ways for regenerative therapy. The purpose of bioprinting is to create the internal plants in vitro. However, it is difficult to culture and vascularize printed tissue in vitro. In order to overcome this difficulty, in situ printing is presented to print the tissue directly on the injured or defective site, using the natural microenvironment in vivo to make the printed tissue mature. This article reviews the technology, advantages and research status of in situ bioprinting and briefly introduces the future direction of in situ bioprinting.

Key words: in situ bioprinting, tissue regeneration, bioink

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