上海交通大学学报(医学版) ›› 2021, Vol. 41 ›› Issue (2): 233-240.doi: 10.3969/j.issn.1674-8115.2021.02.017

• 综述 • 上一篇    

蛋白质组学技术在妇科疾病研究中的应用

黄原昕(), 赖东梅()   

  1. 上海交通大学医学院附属国际和平妇幼保健院上海市胚胎源性疾病重点实验室,上海 200030
  • 收稿日期:2020-07-30 出版日期:2021-02-28 发布日期:2021-03-11
  • 通讯作者: 赖东梅 E-mail:sylviehyx@outlook.com;laidongmei@hotmail.com
  • 作者简介:黄原昕(1996—),女,硕士生;电子信箱:sylviehyx@outlook.com
  • 基金资助:
    国家重点研发计划(2018YFC1004800);国家自然科学基金(81971334);上海市教育委员会高峰高原学科建设计划(20152236)

Application of proteomics to the study of gynecological diseases

Yuan-xin HUANG(), Dong-mei LAI()   

  1. Shanghai Key Laboratory of Embryo Original Diseases, The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Received:2020-07-30 Online:2021-02-28 Published:2021-03-11
  • Contact: Dong-mei LAI E-mail:sylviehyx@outlook.com;laidongmei@hotmail.com
  • Supported by:
    National Key Research and Development Project of China(2018YFC1004800);National Natural Science Foundation of China(81971334);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152236)

摘要:

蛋白质组学是现阶段生物医学研究的核心内容之一。其研究内容涵盖了对信号转导、细胞增殖分化、蛋白质翻译后修饰等生物过程的探索,以及对疾病分子标志物和药物靶标的寻找。该文概述了基于质谱的蛋白质组学技术在妇科常见疾病研究中的应用,包括在多囊卵巢综合征、早发性卵巢功能不全、卵巢癌、子宫内膜癌、宫颈癌的发病机制及生物标志物研究中的应用。

关键词: 蛋白质组学, 多囊卵巢综合征, 早发性卵巢功能不全, 卵巢癌, 子宫内膜癌, 宫颈癌

Abstract:

At present, proteomics is one of the core contents of biomedical research. Its research includes the exploration of biological processes such as signal transduction, cell proliferation and differentiation, protein translation and modification, as well as the search for biomarkers and drug targets of diseases. This review summarizes the application of mass spectrometry-based proteomics to the studies of pathogenesis and biomarkers of common gynecological diseases, including polycystic ovary syndrome, premature ovarian insufficiency, ovarian cancer, endometrial cancer and cervical cancer.

Key words: proteomics, polycystic ovary syndrome, premature ovarian insufficiency, ovarian cancer, endometrial cancer, cervical cancer

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