上海交通大学学报(医学版) ›› 2021, Vol. 41 ›› Issue (2): 246-250.doi: 10.3969/j.issn.1674-8115.2021.02.019

• 综述 • 上一篇    

黄芩苷抗肿瘤作用机制的研究进展

刘梦珂(), 纪濛濛, 程林, 黄金艳, 孙晓建, 赵维莅, 王黎()   

  1. 上海交通大学医学院附属瑞金医院血液科,上海市血液学研究所,医学基因组学国家重点实验室,国家转化医学研究中心,上海 200025
  • 收稿日期:2020-01-03 出版日期:2021-02-28 发布日期:2021-03-11
  • 通讯作者: 王黎 E-mail:lmk0619@163.com;wl_wangdong@126.com
  • 作者简介:刘梦珂(1996—),女,硕士生;电子信箱:lmk0619@163.com
  • 基金资助:
    国家自然科学基金(81520108003);上海市科学技术委员会课题(16JC1405800);上海市杰出青年医学人才培养资助计划;上海市教育委员会高峰高原学科建设计划(20152206);上海市人才基金(2017079);上海交通大学医学院高水平地方高校创新团队(SSMU-ZLCX20180801)

Research progress in anti-tumor effect and mechanism of baicalin

Meng-ke LIU(), Meng-meng JI, Lin CHENG, Jin-yan HUANG, Xiao-jian SUN, Wei-li ZHAO, Li WANG()   

  1. Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Institute of Hematology; State Key Laboratory of Medical Genomics; National Research Center for Translational Medicine, Shanghai 200025, China
  • Received:2020-01-03 Online:2021-02-28 Published:2021-03-11
  • Contact: Li WANG E-mail:lmk0619@163.com;wl_wangdong@126.com
  • Supported by:
    National Natural Science Foundation of China(81520108003);Project of Science and Technology Commission of Shanghai Municipality(16JC1405800);Shanghai Outstanding Youth Medical Talents Training Funding Program;Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152206);Shanghai Talent Development Fund(2017079);Innovative Research Team of High-Level Local Universities in Shanghai(SSMU-ZLCX20180801)

摘要:

黄芩苷是从中药黄芩中提取出来的一种黄酮类化合物。研究表明其作为黄芩的有效成分之一,在抗氧化、抗炎症和抗病毒等方面均具有疗效。随着研究的深入,黄芩苷在抗肿瘤方面的作用被逐渐地认识,其对肿瘤的影响和抗肿瘤的作用机制,如阻滞肿瘤细胞周期、诱导肿瘤细胞凋亡、防治肿瘤转移和调节肿瘤微环境等,使其成为中药抗肿瘤研究的新热点。该文对黄芩苷抗肿瘤作用的研究现状进行综述,以期增进对其抗肿瘤机制的认识,为肿瘤治疗提供新的思路。

关键词: 黄芩苷, 抗肿瘤, 肿瘤凋亡, 肿瘤转移, 肿瘤微环境

Abstract:

Baicalin is one of the flavonoids extracted from the root of Chinese herb Scutellariabaicalensis, which is proved to be an effective component in fields of anti-oxidant, anti-inflammation and anti-virus. Based on further studies, baicalin is gradually known to have anti-tumor function. It has an impact on tumor via multiple mechanisms such as induction of tumor cell cycle arrest, induction of apoptosis of tumor cell, inhibition of tumor metastasis and regulation of tumor microenvironment, ranking it a hotspot in Chinese medicine of anti-tumor therapy. This article comprehensively reviews the previous studies on the anti-tumor effect of baicalin, in order to promote understanding of its anti-tumor mechanisms and provide a new insight in anti-tumor therapy.

Key words: baicalin, anti-tumor, tumor apoptosis, tumor metastasis, tumor microenvironment

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