›› 2009, Vol. 29 ›› Issue (10): 1246-.

• 综述 • 上一篇    下一篇

代谢组学在恶性肿瘤中的应用

樊 星, 综述;李军民, 陈赛娟, 审校   

  1. 上海交通大学 医学院瑞金医院 上海血液学研究所, 上海 200025
  • 出版日期:2009-10-25 发布日期:2009-10-26
  • 通讯作者: 陈赛娟, 电子信箱: sjchen@stn.sh.cn。
  • 作者简介:樊 星(1986—), 女, 硕士生;电子信箱: fx-86@163.com。

Application of metabolomics in malignant tumors

FAN Xing, reviewer;LI Jun-min, CHEN Sai-juan, reviser   

  1. Shanghai Institute of Hematology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2009-10-25 Published:2009-10-26

摘要:

代谢组学是系统生物学的分支之一,应用核磁共振和质谱等技术检测各种体液的代谢物变化,研究各种代谢物分子及其功能,有助于发现相关疾病发生早期的代谢组标志物簇,深入理解相关病理发生的分子机制,为恶性肿瘤的早期诊断及个体化治疗等方面提供广阔的应用前景。

关键词: 代谢组学, 恶性肿瘤, 早期诊断, 分子标记物, 个体化治疗

Abstract:

Metabolomics is one of the branches of systems biology, which employs nuclear magnetic resonance and mass spectrometry technologies to detect the abnormal metabolites from a variety of body fluids. Study of various molecules and their functions may help to find the disease-related early metabolic marker clusters, understand the molecular mechanism of pathogenesis, which provides broad prospects for the early diagnosis and individualized treatment of malignant tumors.

Key words: metabolomics, malignant tumor, early diagnosis, biomaker, individualized , treatment

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