上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (7): 877-.

• 综述 • 上一篇    下一篇

供者特异性输注诱导肾移植受者免疫耐受的研究进展

黄君龄, 综述；王祥慧, 审校   

  1. 上海交通大学 医学院瑞金医院泌尿外科, 上海 200025
  • 出版日期:2009-07-25 发布日期:2009-09-16
  • 通讯作者: 王祥慧, 电子信箱： wxh4270@sina.com。
  • 作者简介:黄君龄（1981—）, 女, 硕士生；电子信箱: jenny8164@hotmail.com。

Research progress of immune tolerance induced by donor specific transfusion in renal transplantation

HUANG Jun-ling, reviewer；WANG Xiang-hui, reviser   

  1. Department of Urology, Ruijin Hospital,School of Medicine,Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2009-07-25 Published:2009-09-16

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摘要：

随着器官移植近半个世纪的发展，当前临床同种异体肾脏移植的主要热点已经转移到低毒性免疫抑制药物及其方案的应用，以及诱导移植受者产生针对供者的特异性免疫低应答或无应答技术的研究。现阶段诱导免疫耐受的有效方法，主要有供者特异性输血和供者特异性骨髓移植。文章就这两种方法的研究背景、机制以及临床应用进展进行综述。

关键词: 肾移植, 供者特异性输血, 供者特异性骨髓移植, 免疫耐受, 嵌合体

Abstract:

With the development of organ transplantation for nearly half a century, currently the hot issues in clinical renal transplantation have already shifted to the application of low toxicity immunosuppressive drugs and their projects, as well as the research of technique which induces low or no immunity response to the specific donor. At present the main effective strategies of inducing immune tolerance are donor specific blood transfusion and donor specific bone marrow transplantation.This article summarizes the background, mechanism and clinical application of these two strategies.

Key words: renal transplantation, donor specific blood transfusion, donor specific bone marrow transplantation, immune tolerance, chimerism