›› 2009, Vol. 29 ›› Issue (7): 886-.

• 综述 • 上一篇    下一篇

抑制血管内皮生长因子活性治疗角膜新生血管形成

王嘉因, 综述;柯碧莲, 审校   

  1. 上海交通大学 第一人民医院眼科, 上海 200080
  • 出版日期:2009-07-25 发布日期:2009-09-16
  • 通讯作者: 柯碧莲, 电子信箱:kebilian@yahoo.com。
  • 作者简介:王嘉因(1984—), 男, 硕士生;电子信箱: wjypub@yahoo.cn。

Research progress in inhibition of corneal neovascularization by anti-VEGF therapy

WANG Jia-yin, reviewer;KE Bi-lian, reviser   

  1. Department of Ophthalmology, The First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2009-07-25 Published:2009-09-16

摘要:

角膜新生血管常继发于各类眼表疾病,引起角膜瘢痕和角膜移植术后排异反应,并可严重影响视力。近年研究发现,血管内皮生长因子(VEGF)在角膜新生血管化过程中起重要作用,而大量新型抗VEGF技术的问世为治疗角膜新生血管带来了希望。文章阐述了各种抑制VEGF的方法在治疗角膜新生血管方面的研究进展。

关键词: 角膜新生血管, 血管内皮生长因子, 治疗

Abstract:

Corneal neovascularization is a significant and sightthreatening complication of many ocular surface disorders, and may cause corneal scar and rejection reaction after corneal grafting. Recent studies have revealed that vascular endothelial growth factor (VEGF) plays an important role in corneal neovascularization, and inhibition of VEGF has become a main strategy for treatment of corneal neovascularization. This article reviews the research progress in inhibition of corneal neovascularization by antiVEGF therapy.

Key words: corneal neovascularization, vascular endothelial growth factor, treatment