上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (2): 229-.

• 综述 • 上一篇    下一篇

活性氧介导预处理和后处理心肌保护效应研究的进展

辛平, 综述；朱伟, 魏盟, 审校   

  1. 上海交通大学 第六人民医院心内科, 上海 200233
  • 出版日期:2010-02-25 发布日期:2010-02-25
  • 通讯作者: 魏 盟, 电子信箱: mrweei@sina.com。
  • 作者简介:辛 平（1979—）, 女, 博士生；电子信箱: xp197929@yahoo.com.cn。
  • 基金资助:

    上海交通大学医学院“博士创新基金”（BXJ0932）

Research advance in role of ROS in cardioprotection offered by preconditioning or postconditioning

XIN Ping, reviewer；ZHU Wei, WEI Meng, reviser   

  1. Department of Cardiology, The Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2010-02-25 Published:2010-02-25
  • Supported by:

    Shanghai Jiaotong University School of Medicine Foundation, BXJ0932

PDF (PC)

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摘要：

活性氧（ROS）在心肌再灌注损伤机制中发挥重要作用。然而大量的研究证实，ROS为预处理和后处理心肌保护效应相关的氧化还原信号通路的重要组成部分。该文阐述了ROS的定义、来源和检测方法，并就ROS在预处理或后处理心肌保护信号通路中的作用及其对ROS的影响进行了综述。

关键词: 活性氧, 心肌再灌注损伤, 预处理, 后处理

Abstract:

Reactive oxygen species (ROS) play an important role in the cardiac ischemic and reperfusion injury. However, accumulating evidences have demonstrated that ROS are pivotal components of redox signaling cascade relevant to cardioprotection induced by either preconditioning or postconditioning. In this review, the definition, source and detection methods of ROS are introduced. Besides, the role of ROS in the cardioprotection offered by preconditioning or postconditioning and the effects of either preconditioning or postconditioning on ROS are summarized.

Key words: reactive oxygen species, myocardial reperfusion injury, preconditioning, postconditioning