上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (6): 651-.

• 专题报道（抑郁障碍研究） • 上一篇    下一篇

脑源性神经营养因子在抑郁症发作病理机制中的作用

李则挚, 综述；洪 武, 方贻儒, 审校   

  1. 上海交通大学 |医学院附属精神卫生中心心境障碍科, 上海 200030
  • 出版日期:2010-06-25 发布日期:2010-06-28
  • 通讯作者: 方贻儒, 电子信箱: yirufang@yahoo.com.cn。
  • 作者简介:李则挚（1981—）, 男, 住院医师, 博士生；电子信箱: lizezhi1981@yahoo.cn。
  • 基金资助:

    “十五”国家科技攻关计划（2004BA720A21-02）；国家高技术研究发展计划（“863”计划）（2006AA02Z430）；上海市“登山行动计划”（064119533）；上海市公共卫生优秀青年人才培养项目（08GWQ075）

Role of brain-derived neurotrophic factor in pathological mechanism of major depressive disorder episode

LI Ze-zhi, reviewer；HONG Wu, FANG Yi-ru, reviser   

  1. Division of Mood Disorder, Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2010-06-25 Published:2010-06-28
  • Supported by:

    National Key Technologies R&D Program of “10th Five-Year Plan”, 2004BA720A21-02；Hi-Tech Research and Development Program of China,“863” Program, 2006AA02Z430；Shanghai “Climbing Mountain Action Plan” Program, 064119533；Shanghai Municipal Health Bureau Foundation, 08GWQ075

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摘要：

抑郁症的脑源性神经营养因子（BDNF）假说认为，BDNF减少在抑郁症的病理生理机制中起着重要的作用，而且其恢复可能与抗抑郁治疗有关。该理论已经得到了越来越多的新证据证明。BDNF能通过多种途径调控神经细胞的发生、生存、生长、分化和凋亡，并直接参与了神经突触的可塑性和重构，这可能是BDNF参与抑郁症发病和治疗的重要机制。该文就近来的BDNF与抑郁症的相关研究进行综述。

关键词: 脑源性神经营养因子, 抑郁症, 病理机制

Abstract:

The brain-derived neurotrophic factor (BDNF) hypothesis of depression postulates that the decrease of BDNF plays a major role in the pathophysiology of major depressive disorder, and its restoration may be associated with the efficacy of antidepressant treatment. This theory has been confirmed by increasingly more evidences. BDNF plays a critical role in neurogenesis, neuronal survival, development, differentiation and regeneration, and directly involves in synaptic plasticity and reconstruction, which is probably the important molecular mechanism responsible for the onset and antidepressant action of depression. The research advance on relationship between BDNF and major depressive disorder is reviewed in this paper.

Key words: brain-derived neurotrophic factor, major depressive disorder, pathological mechanism