上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (7): 967-.doi: 10.3969/j.issn.1674-8115.2011.07.021

• 论著（临床研究） • 上一篇    下一篇

卵巢低反应对体外受精后妊娠高血压疾病发生的影响

马 珏1, 孙晓溪2, 吴 煜1, 顾 玮1, 李 路2   

  1. 1.上海交通大学 医学院附属国际和平妇幼保健院, 上海 200030； 2.复旦大学附属妇产科医院上海集爱遗传与不育诊疗中心, 上海 200011
  • 出版日期:2011-07-28 发布日期:2011-07-27
  • 通讯作者: 李 路, 电子信箱: liluzab@hotmail.com。
  • 作者简介:马 珏（1980—）, 女, 住院医师, 硕士；电子信箱: mary_0802@yahoo.com.cn。

Effects of ovarian poor response on incidences of hypertensive disorders complicating pregnancy after in vitro fertilization

MA Jue1, SUN Xiao-xi2, WU Yu1, GU Wei1, LI Lu2   

  1. 1.International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China； 2.Shanghai Jiai Genetics &|IVF Center, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
  • Online:2011-07-28 Published:2011-07-27

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摘要：

目的 探讨卵巢低反应对接受体外受精-胚胎移植（IVF-ET）患者妊娠期高血压疾病发生率的影响。方法 将接受IVF-ET后成功分娩的患者（≤35岁）分为两组：卵巢低反应组（获卵≤4个，n=92）和卵巢正常反应组（获卵8～12个，n=92）。针对年龄、不孕类型、每日重组卵泡刺激素剂量、单胎或双胎妊娠和治疗方案（IVF/ICSI）相互配对，比较两组妊娠期高血压和子前期的发生率以及妊娠结局。结果 卵巢低反应组与正常反应组比较，妊娠期高血压发生率和子前期发生率的差异均无统计学意义（P>0.05）；两组胎儿出生体质量、分娩孕周、顺产率和活产率比较，差异也无统计学意义（P>0.05）。结论 卵巢低反应对经IVF-ET受孕妇女妊娠期高血压疾病的发生无明显影响。

关键词: 体外受精-胚胎移植, 卵巢低反应, 妊娠高血压疾病, 子前期

Abstract:

Objective To investigate the effects of ovarian poor response on incidences of hypertensive disorders complicating pregnancy after in vitro fertilization-embryo transfer (IVF-ET). Methods Patients (≤35 years old）with successful delivery after IVF-ET were divided into ovarian poor response group (number of retrieved oocytes≤4, n=92) and ovarian normal response group (number of retrieved oocytes 8-12, n=92). Patients in two groups were matched for age, type of infertility, daily dose of recombinant follicle-stimulating hormone, singleton or twin pregnancy and therapeutic regimen (in vitro fertilization/intracytoplasmic sperm injection), and the incidences of hypertensive disorders complicating pregnancy and preeclampsia were compared between two groups. Results There was no significant difference in the incidences of hypertensive disorders complicating pregnancy and preeclampsia between ovarian poor response group and ovarian normal response group (P>0.05). There was also no significant difference in the birth weight of neonates, duration of pregnancy, rates of viginal delivery and rates of live birth between two groups (P>0.05). Conclusion Ovarian poor response may have no significant effect on incidences of hypertensive disorders complicating pregnancy after IVF-ET.

Key words: in vitro fertilization-embryo transfer, ovarian poor response, hypertensive disorders complicating pregnancy, preeclampsia