›› 2012, Vol. 32 ›› Issue (8): 1010-.doi: 10.3969/j.issn.1674-8115.2012.08.011

• 专题报道(不孕不育症及辅助生殖技术) • 上一篇    下一篇

PDE5抑制剂对精子活力及受精功能影响的研究进展

卢克敏, 卢 慧, 李 铮   

  1. 上海交通大学 医学院附属仁济医院泌尿外科 上海市人类精子库 上海市男科学研究所精子发育与遗传实验室, 上海 200001
  • 出版日期:2012-08-28 发布日期:2012-08-29
  • 通讯作者: 李 铮, 电子信箱: doc.zheng.li@gmail.com。
  • 作者简介:卢克敏(1988—), 男, 技师, 学士;电子信箱: lukemin999@163.com;卢 慧(1978—), 女, 实习研究员, 硕士;电子信箱: lzaloe@gmail.com。
  • 基金资助:

    上海市科委重点课题(10JC1409900)

Research progress of effects of PDE5 inhibitors on sperm motility and fertilizing capacity

LU Ke-min, LU Hui, LI Zheng   

  1. Department of Urology, Shanghai Human Sperm Bank, Sperm Development and Genetics Laboratory, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China
  • Online:2012-08-28 Published:2012-08-29
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 10JC1409900

摘要:

磷酸二酯酶-5 (PDE5)抑制剂常用于治疗阴茎勃起功能障碍。近年来,研究发现PDE5抑制剂对精子的活力和受精功能有影响,尤其在适当药物浓度时能显著提高精子运动能力。该文就PDE5抑制剂对精子活力和受精功能的影响进行综述。

关键词: 磷酸二酯酶-5抑制剂, 精子, 活力, 受精

Abstract:

Phosphodiesterase-5 (PDE5) inhibitors are commonly used in the treatment of penile erectile dysfunction (ED). Recent studies have revealed that PDE5 inhibitors have impact on sperm motility and fertilizing capacity, and can significantly improve sperm motility in the appropriate concentration. The effects of PDE5 inhibitors on sperm motility and fertilizing capacity are reviewed in this paper.

Key words: phosphodiesterase-5 inhibitor, spermatozoa, motility, fertilization