上海交通大学学报（医学版）

上海交通大学学报（医学版）

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PI3K/AKT/mTOR信号转导途径在嗜铬细胞瘤发生和发展中的作用及其联合靶向治疗

成 康，孙福康   

  1. 上海交通大学医学院附属瑞金医院泌尿外科， 上海 200025
  • 出版日期:2015-01-28 发布日期:2015-01-29
  • 通讯作者: 孙福康, 电子信箱: sunfukang6@126.com。
  • 作者简介:成 康（1990—）， 男， 硕士生; 电子信箱: chengkang4523@gmail.com。

Role of PI3K/AKT/mTOR signaling pathway in development and progress of pheochromocytoma and its combined targeted therapies

CHENG Kang, SUN Fu-kang   

  1. Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2015-01-28 Published:2015-01-29

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摘要：

PI3K/AKT/mTOR信号途径在嗜铬细胞瘤的发生和发展中发挥着重要的作用。单独抑制其中某个靶点却会导致对于上游靶点的反馈激活以及平行信号途径的激活，导致肿瘤对针对这一信号途径抑制剂的抵抗。该文就PI3K/akt/mTOR信号通路在嗜铬细胞瘤发生和发展中的作用以及针对这一信号通路的靶向治疗，特别是多靶点多信号途径的联合靶向治疗的最新研究进展进行综述。

关键词: PI3K/AKT/mTOR信号途径, 嗜铬细胞瘤, 联合靶向治疗

Abstract:

PI3K/AKT/mTOR signaling pathway plays a vital role in the development and progress of pheochromocytoma. However, blocking one of the targets alone may activate the feedback loop of upstream targets and the parallel signaling pathways, which causes the resistance to PI3K/AKT/mTOR pathway inhibitors. This paper reviews the role of PI3K/AKT/mTOR signaling pathway in the development and progress of pheochromocytoma and latest research progresses of relevant targeted therapies, especially targeted therapies combined with multi-target and multi-pathway.

Key words: PI3K/AKT/mTOR signaling pathway, pheochromocytoma, combined targeted therapy