上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (11): 1325-.doi: 10.3969/j.issn.1674-8115.2019.11.018

• 综述 • 上一篇    下一篇

T细胞免疫在脓毒症继发侵袭性真菌感染中作用的研究进展

赵乙汜1，余应喜1，林时辉2，徐 昉1, 2   

  1. 1.重庆医科大学附属第一医院重症医学科，重庆400016；2.重庆医科大学基础医学院病理生理学教研室，重庆400016
  • 出版日期:2019-11-28 发布日期:2019-12-16
  • 通讯作者: 徐 昉，电子信箱：xufang828@126.com。
  • 作者简介:赵乙汜（1995—），男，硕士生；电子信箱：zhaoyisi14@foxmail.com。
  • 基金资助:
    国家自然科学基金（81873928，81801894，81570069）

Advances in the study of T cell immunity in invasive fungal infections secondary to sepsis

ZHAO Yi-si1, YU Ying-xi1, LIN Shi-hui2, XU Fang1, 2   

  1. 1. Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; 2.Department of Pathophysiology, The Basic Medicine of Chongqing Medical University, Chongqing 400016, China
  • Online:2019-11-28 Published:2019-12-16
  • Supported by:
    National Natural Science Foundation of China, 81873928, 81801894, 81570069

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摘要： 侵袭性真菌感染（invasive fungal infections，IFI）是一种具有很高发病率及死亡率的疾病，且多见于院内感染，特别是在脓毒症时，继发IFI的概率大大增加。脓毒症出现免疫抑制会影响T细胞免疫功能，不同的T细胞亚群对IFI各种真菌病原体都有不同的作用。此综述探讨了脓毒症继发IFI中T细胞免疫的病理生理变化、作用机制及治疗方法的研究进展，旨在对脓毒症继发IFI中T细胞的作用做一个总结，并介绍最新研究出的免疫治疗方法。

关键词: 侵袭性真菌感染, T淋巴细胞亚群, 脓毒症, 免疫疗法

Abstract:

Invasive fungal infections (IFI) has high morbidity and mortality. It is more common in hospital infections, and especially in sepsis, the risk of secondary IFI is increased. Immunosuppression of sepsis may affect immune function of T cells, and various T cells subsets have different effects on various fungal pathogens of IFI. The review discusses the pathophysiological processes, mechanism and therapeutic methods of T cell immunity in IFI secondary to sepsis, into summarize the role of T cells in IFI secondary to sepsis and introduce the new immunotherapy.

Key words: invasive fungal infections, T-cell subsets, sepsis, immunotherapy

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