上海交通大学学报(医学版)

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肝X受体在脂代谢中的研究进展

高桂荣,董 莹   

  1. 上海交通大学  医学院附属仁济医院内分泌科, 上海 200127
  • 出版日期:2013-11-28 发布日期:2013-12-03
  • 通讯作者: 董 莹, 电子信箱: 13472519882@ 163.com。
  • 作者简介:高桂荣(1988—), 女, 硕士生; 电子信箱: chinaguirongrong@sina.com。
  • 基金资助:

    上海市科委基金(124119a5700)

Advanced research of liver X receptor in lipid metabolism

GAO Gui-rong, DONG Ying   

  1. Department of Endocrinology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2013-11-28 Published:2013-12-03
  • Supported by:

    Foundation of Science and Technology Commission of Shanghai, 124119a5700

摘要:

肝X受体(LXR)是配体依赖型转录因子,在脂代谢中起着重要的调节作用。由于其调脂作用而产生的降胆固醇和抗动脉粥样硬化效应,成为临床新药的研发靶点受到广泛关注。文章通过对LXR的结构、功能和在脂代谢中的分子作用机制及其研究进展作一系统阐述,为科研和新药开发提供一定的理论依据和指导。

关键词: 肝X受体, 脂代谢, 三磷酸腺苷结合盒转运蛋白, 载脂蛋白E

Abstract:

Liver X receptors (LXRs) are ligand-activated nuclear transcription factor, which play a crucial role in lipid metabolism. Recently, LXRs attracts a widely attention to us for its effects on keeping cholesterol homeostasis and anti-atherosclerosis. It might be worthy of development as a new drug target for clinic treatment. This review systematically illustrated the structure, function, and the molecular mechanism of LXRs in lipid metabolic regulation, in order to provide the principles and directions for further study.

Key words: liver X receptor, lipid metabolism, ATP-binding cassette transporter protein, apolipoprotein E