上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

长期使用喹硫平对阿尔茨海默病患者认知功能的影响

沈莉莉，谢 帆，姚培芬，李 霞，卢卫红，陈文忠，宋立升   

  1. 上海交通大学 医学院附属精神卫生中心， 上海 200030
  • 出版日期:2014-02-28 发布日期:2014-03-25
  • 通讯作者: 宋立升, 电子信箱: slslulu@yahoo.com.cn。
  • 作者简介:沈莉莉（1973—）， 女， 主治医师， 学士; 电子信箱: lilishen2005@126.com。
  • 基金资助:

    上海市卫生局基金（2010007）

Long-term quetiapine therapy on the cognitive function in patients with Alzheimer′s disease

SHEN Li-li, XIE Fan, YAO Pei-fen, LI Xia, LU Wei-hong, CHEN Wen-zhong, SONG Li-sheng   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2014-02-28 Published:2014-03-25
  • Supported by:

    Shanghai Municipal Health Bureau Foundation, 2010007

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摘要：

目的 探讨长期使用喹硫平治疗对阿尔茨海默病（AD）患者认知功能的影响。方法 纳入51例伴有精神行为症状的门诊AD患者，随机分为治疗组（服用喹硫平，n=26）和对照组（未服用喹硫平，n=25）。分别于治疗前（基线）、治疗3个月和6个月时采用认知能力筛查量表（CASI）和老年性痴呆评定量表认知分量表（ADAS-cog）评估两组患者的认知功能。结果 两组AD患者的CASI和ADAS-cog基线评分比较差异无统计学意义（P>0.05）；3个月后，两组的CASI和ADAS-cog评分均有所提高，但差异无统计学意义（P>0.05）；6个月后，两组的CASI及ADAScog评分进一步提高，其中治疗组的ADAS-cog评分显著高于对照组，差异有统计学意义（P<0.05）。结论 长期使用喹硫平治疗可能对AD患者的认知功能产生不利影响。

关键词: 阿尔茨海默病, 喹硫平, 认知功能

Abstract:

Objective To investigate the effect of long-term administration of quetiapine on the cognitive function of patients with Alzheimer′s disease (AD). MethodsFifty-one AD outpatients with psychological and behavioral symptoms were randomly divided into treatment group (taking quetiapine, n=26) and control group (n=25). Cognitive Abilities Screening Instrument (CASI) and Alzheimer′s Disease Assessment Scale (ADAS-cog) were used to assess the cognitive function of two groups before treatment (baseline), and three months, six months after treatment. Results The baseline scores of CASI and ADAS-cog of two groups were not statistically significant (P>0.05). Three months after treatment, the scores of CASI and ADAS-cog increased but were not statistically significant (P>0.05). Six months after treatment, the scores of CASI and ADAS-cog further increased. The scores of treatment group were obviously higher than those of the control group and statistically significant (P<0.05). Conclusion Long-term administration of quetiapine may cause an adverse impact on the cognitive function of AD patients.

Key words: Alzheimer′s disease, quetiapine, cognitive function